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Tdrd12 Gene Detail
Summary
  • Symbol
    Tdrd12
  • Name
    tudor domain containing 12
  • Synonyms
    2410004F06Rik, 2410070K17Rik, ecat8, EG434165, G1-476-14, repro23
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919231
    NCBI Gene: 71981
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:35168523-35237170 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 21.37 cM, cytoband B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    564 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919231
 protein coding gene Chr7:35166366-35237206 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032090
 protein coding gene Chr7:34861999-34931971 (-)
A/J MGP_AJ_G0032070
 protein coding gene Chr7:33929104-34003413 (-)
AKR/J MGP_AKRJ_G0032003
 protein coding gene Chr7:34757812-34838218 (-)
BALB/cJ MGP_BALBcJ_G0032077
 protein coding gene Chr7:34222054-34292082 (-)
C3H/HeJ MGP_C3HHeJ_G0031794
 protein coding gene Chr7:35640985-35711936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032554
 protein coding gene Chr7:36583052-36653342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029587
 protein coding gene Chr7:34649105-34731408 (-)
CAST/EiJ MGP_CASTEiJ_G0031129
 protein coding gene Chr7:26802262-26876330 (-)
CBA/J MGP_CBAJ_G0031762
 protein coding gene Chr7:37722340-37792916 (-)
DBA/2J MGP_DBA2J_G0031914
 protein coding gene Chr7:33779758-33849235 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031991
 protein coding gene Chr7:35193871-35264603 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031907
 protein coding gene Chr7:36735009-36804957 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032569
 protein coding gene Chr7:34299954-34371886 (-)
PWK/PhJ MGP_PWKPhJ_G0030851
 protein coding gene Chr7:27111684-27181820 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030686
 protein coding gene Chr7:23864944-23937390 (-)
WSB/EiJ MGP_WSBEiJ_G0031239
 protein coding gene Chr7:34851287-34929689 (-)



Homology
more
  • Human Ortholog
    TDRD12, tudor domain containing 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TDRD12, tudor domain containing 12
  • Synonyms
    ECAT8
  • Links
    NCBI Gene ID: 91646
    neXtProt AC: NX_Q587J7
    UniProt: Q587J7

  • Chr Location
    19q13.11; chr19:32719753-32829580 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous males are infertile with small testes. Spermatogenesis is arrested predominantly at the pachytene spermatocyte stage. Retrotransposon hopping is derepressed in germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    35
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030491 Ensembl Gene Model | MGI Sequence Detail 68648 C57BL/6J ±  kb
    transcript ENSMUST00000193633 Ensembl | MGI Sequence Detail 3651 Not Applicable  
    polypeptide ENSMUSP00000141796 Ensembl | MGI Sequence Detail 1216 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920941, MGI:3512804, MGI:3645452
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342546 Schimenti JC, et al., Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome". Biol Reprod. 2018 Dec 1;99(6):1119-1128
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory