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Dcaf7 Gene Detail
Summary
  • Symbol
    Dcaf7
  • Name
    DDB1 and CUL4 associated factor 7
  • Synonyms
    1700012F10Rik, 2610037L01Rik, Wdr68
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919083
    NCBI Gene: 71833
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:105927698-105950150 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.89 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919083
 protein coding gene Chr11:105927698-105950150 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019291
 protein coding gene Chr11:109302086-109328512 (+)
A/J MGP_AJ_G0019259
 protein coding gene Chr11:104653378-104676962 (+)
AKR/J MGP_AKRJ_G0019228
 protein coding gene Chr11:107782077-107804587 (+)
BALB/cJ MGP_BALBcJ_G0019233
 protein coding gene Chr11:105057292-105081691 (+)
C3H/HeJ MGP_C3HHeJ_G0019042
 protein coding gene Chr11:108072304-108095754 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019683
 protein coding gene Chr11:112661880-112684339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017308
 protein coding gene Chr11:101943464-101965512 (+)
CAST/EiJ MGP_CASTEiJ_G0018595
 protein coding gene Chr11:109123792-109146120 (+)
CBA/J MGP_CBAJ_G0019011
 protein coding gene Chr11:117345021-117372655 (+)
DBA/2J MGP_DBA2J_G0019123
 protein coding gene Chr11:104127730-104151361 (+)
FVB/NJ MGP_FVBNJ_G0019114
 protein coding gene Chr11:103632300-103654687 (+)
LP/J MGP_LPJ_G0019193
 protein coding gene Chr11:109754964-109779627 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019144
 protein coding gene Chr11:116642851-116665288 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019720
 protein coding gene Chr11:108260453-108283133 (+)
PWK/PhJ MGP_PWKPhJ_G0018360
 protein coding gene Chr11:105221321-105245324 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018151
 protein coding gene Chr11:108035603-108059267 (+)
WSB/EiJ MGP_WSBEiJ_G0018646
 protein coding gene Chr11:108233681-108259537 (+)



Homology
more
  • Human Ortholog
    DCAF7, DDB1 and CUL4 associated factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCAF7, DDB1 and CUL4 associated factor 7
  • Synonyms
    AN11, HAN11, SWAN-1, WDR68
  • Links
    NCBI Gene ID: 10238
    neXtProt AC: NX_P61962
    UniProt: P61962

  • Chr Location
    17q23.3; chr17:63550222-63594286 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    13
  • cDNA Data
    17
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71833 NCBI Gene Model | MGI Sequence Detail 22453 C57BL/6J ±  kb
    transcript NM_027946 RefSeq | MGI Sequence Detail 5765 C57BL/6  
    polypeptide P61963 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1922876, MGI:2144685
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:266543 Zhang YL, et al., DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018 Sep 14;37(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory