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Klhl5 Gene Detail
Summary
  • Symbol
    Klhl5
  • Name
    kelch-like 5
  • Synonyms
    1300013C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919028
    NCBI Gene: 71778
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65264894-65325490 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919028
 protein coding gene Chr5:65264882-65325531 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029572
 protein coding gene Chr5:64750486-64787798 (+)
A/J MGP_AJ_G0029540
 protein coding gene Chr5:62352074-62389144 (+)
AKR/J MGP_AKRJ_G0029488
 protein coding gene Chr5:64322059-64359104 (+)
BALB/cJ MGP_BALBcJ_G0029549
 protein coding gene Chr5:63035900-63072928 (+)
C3H/HeJ MGP_C3HHeJ_G0029272
 protein coding gene Chr5:64668232-64705224 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030003
 protein coding gene Chr5:67433210-67470133 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027243
 protein coding gene Chr5:58416664-58453738 (+)
CAST/EiJ MGP_CASTEiJ_G0028680
 protein coding gene Chr5:63766962-63804162 (+)
CBA/J MGP_CBAJ_G0029241
 protein coding gene Chr5:69611774-69654094 (+)
DBA/2J MGP_DBA2J_G0029387
 protein coding gene Chr5:62365615-62403633 (+)
FVB/NJ MGP_FVBNJ_G0029347
 protein coding gene Chr5:61558400-61595502 (+)
LP/J MGP_LPJ_G0029472
 protein coding gene Chr5:65238718-65275800 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029375
 protein coding gene Chr5:72491710-72531121 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030036
 protein coding gene Chr5:64001126-64038289 (+)
PWK/PhJ MGP_PWKPhJ_G0028404
 protein coding gene Chr5:61341784-61380341 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028238
 protein coding gene Chr5:63310350-63348915 (+)
WSB/EiJ MGP_WSBEiJ_G0028760
 protein coding gene Chr5:64200940-64239198 (+)



Homology
more
  • Human Ortholog
    KLHL5, kelch like family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHL5, kelch like family member 5
  • Links
    NCBI Gene ID: 51088
    neXtProt AC: NX_Q96PQ7
    UniProt: Q96PQ7

  • Chr Location
    4p14; chr4:39044827-39143101 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KLHL5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    79
  • cDNA Data
    71
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71778 NCBI Gene Model | MGI Sequence Detail 60597 C57BL/6J ±  kb
    transcript NM_175174 RefSeq | MGI Sequence Detail 3422 C57BL/6  
    polypeptide NP_780383 RefSeq | MGI Sequence Detail 708 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 71

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Phenotypes 25
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/23/2024
    MGI 6.23     		The Jackson Laboratory