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Hemk1 Gene Detail
Summary
  • Symbol
    Hemk1
  • Name
    HemK methyltransferase family member 1
  • Synonyms
    2310008M14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916786
    NCBI Gene: 69536
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107204283-107215549 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916786
 protein coding gene Chr9:107204281-107217640 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035250
 protein coding gene Chr9:109183643-109194750 (-)
A/J MGP_AJ_G0035229
 protein coding gene Chr9:105222675-105233764 (-)
AKR/J MGP_AKRJ_G0035161
 protein coding gene Chr9:107845404-107857855 (-)
BALB/cJ MGP_BALBcJ_G0035223
 protein coding gene Chr9:104891563-104903112 (-)
C3H/HeJ MGP_C3HHeJ_G0034933
 protein coding gene Chr9:108244757-108255825 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035743
 protein coding gene Chr9:112186447-112197763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032641
 protein coding gene Chr9:102651215-102662442 (-)
CAST/EiJ MGP_CASTEiJ_G0034244
 protein coding gene Chr9:108177478-108188664 (-)
CBA/J MGP_CBAJ_G0034901
 protein coding gene Chr9:116160069-116171240 (-)
DBA/2J MGP_DBA2J_G0035062
 protein coding gene Chr9:104675802-104687258 (-)
FVB/NJ MGP_FVBNJ_G0035010
 protein coding gene Chr9:103437980-103449322 (-)
LP/J MGP_LPJ_G0035138
 protein coding gene Chr9:109392004-109404437 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035049
 protein coding gene Chr9:117748454-117761481 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035764
 protein coding gene Chr9:108111402-108125708 (-)
PWK/PhJ MGP_PWKPhJ_G0033951
 protein coding gene Chr9:104989418-105003096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033786
 protein coding gene Chr9:108178706-108192055 (-)
WSB/EiJ MGP_WSBEiJ_G0034365
 protein coding gene Chr9:107999839-108012931 (-)



Homology
more
  • Human Ortholog
    HEMK1, HemK methyltransferase family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HEMK1, HemK methyltransferase family member 1
  • Synonyms
    HEMK, MPRMC, MTQ1
  • Links
    NCBI Gene ID: 51409
    neXtProt AC: NX_Q9Y5R4
    UniProt: Q9Y5R4

  • Chr Location
    3p21.31; chr3:50569152-50596168 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    23
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032579 Ensembl Gene Model | MGI Sequence Detail 11267 C57BL/6J ±  kb
transcript ENSMUST00000035196 Ensembl | MGI Sequence Detail 2192 Not Applicable  
polypeptide ENSMUSP00000035196 Ensembl | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000032294 MTRF1L release factor glutamine methyltransferase
    (term hierarchy)
  • EC
    2.1.1.297
  • InterPro Domains
    IPR002052 DNA methylase, N-6 adenine-specific, conserved site
    IPR004556 Methyltransferase HemK-like
    IPR007848 Methyltransferase small domain
    IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific
    IPR040758 Release factor glutamine methyltransferase, N-terminal domain
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143281
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory