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Mcrip2 Gene Detail
Summary
  • Symbol
    Mcrip2
  • Name
    MAPK regulated corepressor interacting protein 2
  • Synonyms
    9530058B02Rik, Fam195a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915491
    NCBI Gene: 68241
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26082672-26087738 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.96 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915491
 protein coding gene Chr17:26082672-26087738 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023378
 protein coding gene Chr17:24961058-24968806 (-)
A/J MGP_AJ_G0023337
 protein coding gene Chr17:24236595-24241614 (-)
AKR/J MGP_AKRJ_G0023303
 protein coding gene Chr17:24342142-24348715 (-)
BALB/cJ MGP_BALBcJ_G0023342
 protein coding gene Chr17:24464643-24470062 (-)
C3H/HeJ MGP_C3HHeJ_G0023102
 protein coding gene Chr17:24725745-24731893 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023784
 protein coding gene Chr17:26014409-26020643 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021260
 protein coding gene Chr17:21698862-21703858 (-)
CAST/EiJ MGP_CASTEiJ_G0022604
 protein coding gene Chr17:24612656-24617690 (-)
CBA/J MGP_CBAJ_G0023077
 protein coding gene Chr17:26932315-26941143 (-)
DBA/2J MGP_DBA2J_G0023207
 protein coding gene Chr17:23839247-23844483 (-)
FVB/NJ MGP_FVBNJ_G0023177
 protein coding gene Chr17:23580633-23587253 (-)
LP/J MGP_LPJ_G0023284
 protein coding gene Chr17:25261662-25267794 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023196
 protein coding gene Chr17:26538087-26543087 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023824
 protein coding gene Chr17:24661708-24667784 (-)
PWK/PhJ MGP_PWKPhJ_G0022353
 protein coding gene Chr17:22601243-22606682 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022171
 protein coding gene Chr17:22735634-22740685 (-)
WSB/EiJ MGP_WSBEiJ_G0022667
 protein coding gene Chr17:24714054-24719078 (-)



Homology
more
  • Human Ortholog
    MCRIP2, MAPK regulated corepressor interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCRIP2, MAPK regulated corepressor interacting protein 2
  • Synonyms
    C16orf14, c349E10.1, FAM195A
  • Links
    NCBI Gene ID: 84331
    neXtProt AC: NX_Q9BUT9
    UniProt: Q9BUT9

  • Chr Location
    16p13.3; chr16:636817-648474 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
mice homozygous for a null allele exhibit whitened brown adipose tissue morphology, impaired adaptive thermogenesis, and aberrant branched-chain amino acid and fatty acid metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    2
  • cDNA Data
    42
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68241 NCBI Gene Model | MGI Sequence Detail 5067 C57BL/6J ±  kb
    transcript NR_166093 RefSeq | MGI Sequence Detail 1031 C57BL/6  
    polypeptide Q9CQB2 UniProt | EBI | MGI Sequence Detail 160 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000031090 MAPK regulated corepressor interacting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR029428 Mapk-regulated corepressor-interacting protein
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:316902 Cannavino J, et al., Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2104650118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory