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Tmbim4 Gene Detail
Summary
  • Symbol
    Tmbim4
  • Name
    transmembrane BAX inhibitor motif containing 4
  • Synonyms
    0610007H07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915462
    NCBI Gene: 68212
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:120044731-120060802 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 67.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915462
protein coding gene Chr10:120037495-120060822 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017773
protein coding gene Chr10:123345486-123375081 (+)
A/J MGP_AJ_G0017748
protein coding gene Chr10:118466481-118489986 (+)
AKR/J MGP_AKRJ_G0017711
protein coding gene Chr10:121999727-122024692 (+)
BALB/cJ MGP_BALBcJ_G0017712
protein coding gene Chr10:118854771-118878007 (+)
C3H/HeJ MGP_C3HHeJ_G0017536
protein coding gene Chr10:122204770-122228671 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018167
protein coding gene Chr10:127525406-127552020 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015848
protein coding gene Chr10:112823759-112849928 (+)
CAST/EiJ MGP_CASTEiJ_G0017097
protein coding gene Chr10:122511913-122545515 (+)
CBA/J MGP_CBAJ_G0017505
protein coding gene Chr10:132722009-132751256 (+)
DBA/2J MGP_DBA2J_G0017611
protein coding gene Chr10:117601685-117626997 (+)
FVB/NJ MGP_FVBNJ_G0017606
protein coding gene Chr10:116592631-116618088 (+)
LP/J MGP_LPJ_G0017685
protein coding gene Chr10:123897333-123924709 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017635
protein coding gene Chr10:135337716-135365278 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018208
protein coding gene Chr10:122006531-122034774 (+)
PWK/PhJ MGP_PWKPhJ_G0016881
protein coding gene Chr10:117699309-117724038 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016672
protein coding gene Chr10:120895751-120923072 (+)
WSB/EiJ MGP_WSBEiJ_G0017157
protein coding gene Chr10:122249795-122274448 (+)



Homology
more
  • Human Ortholog
    TMBIM4, transmembrane BAX inhibitor motif containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMBIM4, transmembrane BAX inhibitor motif containing 4
  • Synonyms
    CGI-119, GAAP, LFG4, S1R, ZPRO
  • Links
    NCBI Gene ID: 51643
    neXtProt AC: NX_Q9HC24
    UniProt: Q9HC24

  • Chr Location
    12q14.3; chr12:66135846-66170027 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    3
  • Targeted
    4
  • Genomic Mutations
    1 involving Tmbim4
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68212 NCBI Gene Model | MGI Sequence Detail 16072 C57BL/6J ±  kb
transcript NM_026617 RefSeq | MGI Sequence Detail 808 C57BL/6  
polypeptide Q9DA39 UniProt | EBI | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    cDNA 95

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143748
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:314870 Gatius A, et al., The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons. Front Cell Neurosci. 2019;13:582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory