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Hoga1 Gene Detail
Summary
  • Symbol
    Hoga1
  • Name
    4-hydroxy-2-oxoglutarate aldolase 1
  • Synonyms
    0610010D20Rik, Dhdpsl, Npl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914682
    NCBI Gene: 67432
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42034049-42059392 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 35.67 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914682
 protein coding gene Chr19:42033998-42060128 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025136
 protein coding gene Chr19:41358266-41387444 (+)
A/J MGP_AJ_G0025113
 protein coding gene Chr19:39370792-39395975 (+)
AKR/J MGP_AKRJ_G0025081
 protein coding gene Chr19:40662138-40686732 (+)
BALB/cJ MGP_BALBcJ_G0025107
 protein coding gene Chr19:39431196-39460379 (+)
C3H/HeJ MGP_C3HHeJ_G0024867
 protein coding gene Chr19:40811036-40837196 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025550
 protein coding gene Chr19:42423175-42449140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022964
 protein coding gene Chr19:38722407-38750840 (+)
CAST/EiJ MGP_CASTEiJ_G0024332
 protein coding gene Chr19:40487829-40514931 (+)
CBA/J MGP_CBAJ_G0024847
 protein coding gene Chr19:44510167-44535089 (+)
DBA/2J MGP_DBA2J_G0024979
 protein coding gene Chr19:39220854-39245275 (+)
FVB/NJ MGP_FVBNJ_G0024940
 protein coding gene Chr19:38995395-39019932 (+)
LP/J MGP_LPJ_G0025065
 protein coding gene Chr19:41349039-41374575 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024971
 protein coding gene Chr19:44127131-44152502 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025608
 protein coding gene Chr19:40700920-40727024 (+)
PWK/PhJ MGP_PWKPhJ_G0024081
 protein coding gene Chr19:39097966-39123552 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023885
 protein coding gene Chr19:39446472-39473073 (+)
WSB/EiJ MGP_WSBEiJ_G0024402
 protein coding gene Chr19:40853492-40883035 (+)



Homology
more
  • Human Ortholog
    HOGA1, 4-hydroxy-2-oxoglutarate aldolase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOGA1, 4-hydroxy-2-oxoglutarate aldolase 1
  • Synonyms
    C10orf65, DHDPS2, DHDPSL, HP3, NPL2
  • Links
    NCBI Gene ID: 112817
    neXtProt AC: NX_Q86XE5
    UniProt: Q86XE5

  • Chr Location
    10q24.2; chr10:97584323-97612802 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hoga1 mouse models; 1 with human HOGA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal urinary excretion of oxalate but show increased urine 2,4-dihydroxyglutarate (DHG) levels especially when challenged by the inclusion of hydroxyproline in the diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025176 Ensembl Gene Model | MGI Sequence Detail 25344 C57BL/6J ±  kb
    transcript ENSMUST00000081714 Ensembl | MGI Sequence Detail 1668 Not Applicable  
    polypeptide ENSMUSP00000080414 Ensembl | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Diseases 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:327319 Martinez-Turrillas R, et al., In vivo CRISPR-Cas9 inhibition of hepatic LDH as treatment of primary hyperoxaluria. Mol Ther Methods Clin Dev. 2022 Jun 9;25:137-146
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory