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Nupr1 Gene Detail
Summary
  • Symbol
    Nupr1
  • Name
    nuclear protein transcription regulator 1
  • Synonyms
    2310032H04Rik, Com1, p8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891834
    NCBI Gene: 56312
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126222418-126224642 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.21 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891834
 protein coding gene Chr7:126222418-126230033 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032989
 protein coding gene Chr7:130907428-130914815 (-)
A/J MGP_AJ_G0032972
 protein coding gene Chr7:127444332-127451650 (-)
AKR/J MGP_AKRJ_G0032904
 protein coding gene Chr7:130668103-130675490 (-)
BALB/cJ MGP_BALBcJ_G0032977
 protein coding gene Chr7:127101613-127109000 (-)
C3H/HeJ MGP_C3HHeJ_G0032687
 protein coding gene Chr7:130605194-130612732 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033483
 protein coding gene Chr7:135996636-136005683 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030455
 protein coding gene Chr7:128630784-128638536 (-)
CAST/EiJ MGP_CASTEiJ_G0032015
 protein coding gene Chr7:122392128-122399533 (-)
CBA/J MGP_CBAJ_G0032660
 protein coding gene Chr7:140570390-140580339 (-)
DBA/2J MGP_DBA2J_G0032812
 protein coding gene Chr7:125419866-125427438 (-)
FVB/NJ MGP_FVBNJ_G0032765
 protein coding gene Chr7:125270061-125277448 (-)
LP/J MGP_LPJ_G0032906
 protein coding gene Chr7:132372821-132380208 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032797
 protein coding gene Chr7:141758712-141766099 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033502
 protein coding gene Chr7:129683255-129690573 (-)
PWK/PhJ MGP_PWKPhJ_G0031723
 protein coding gene Chr7:118408308-118415931 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031569
 protein coding gene Chr7:116516127-116523501 (-)
WSB/EiJ MGP_WSBEiJ_G0032128
 protein coding gene Chr7:130658831-130666216 (-)



Homology
more
  • Human Ortholog
    NUPR1, nuclear protein 1, transcriptional regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUPR1, nuclear protein 1, transcriptional regulator
  • Synonyms
    COM1, P8
  • Links
    NCBI Gene ID: 26471
    neXtProt AC: NX_O60356
    UniProt: O60356

  • Chr Location
    16p11.2; chr16:28532708-28539008 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nupr1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
MEFs from homozygous null mice display increased cell proliferation and reduced sensitivity to induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    33
  • cDNA Data
    70
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56312 NCBI Gene Model | MGI Sequence Detail 2225 C57BL/6J ±  kb
    transcript NM_019738 RefSeq | MGI Sequence Detail 639 Not Specified  
    polypeptide Q9WTK0 UniProt | EBI | MGI Sequence Detail 80 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 70
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916880
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:64814 Vasseur S, et al., Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem J. 1999 Oct 15;343 Pt 2:377-83
    • Latest
      J:346082 Santofimia-Castano P, et al., Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras(G12D)-driven tumors. EMBO Mol Med. 2024 Mar;16(3):475-505
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory