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BY367451 Gene Detail
Summary
  • Symbol
    BY367451
  • Name
    cDNA sequence, BY367451
  • Synonyms
    Atxn8os, Klhl1as, Sca8
  • Feature Type
    unclassified non-coding RNA gene
  • IDs
    MGI:1891412
    NCBI Gene: 108639
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr14:96794007-96794446 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891412
 unclassified non-coding RNA gene Chr14:96794007-96794446 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice both homozygous and heterozygous for disruption of this gene develop abnormalities in gait and defects in motor coordination with time. Dendritic atrophy of Purkinje cells is also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    1
  • GO References
    1
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
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  • cDNA Data
    1
Sequences &
Gene Models
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  • All Sequences
    2
Representative SequencesLengthStrain/SpeciesFlank
transcript BY367451 GenBank | ENA | DDBJ | MGI Sequence Detail 440 C57BL/6J  
For the selected sequence
Molecular
Reagents
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  • All nucleic 1
    cDNA 1
References
more
  • Summaries
    All 10
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:62929 Nemes JP, et al., The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). Hum Mol Genet. 2000 Jun 12;9(10):1543-51
  • Latest
    J:140562 Chen WL, et al., SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology. Brain Res. 2008 Oct 3;1233:176-84
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory