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Chdh Gene Detail
Summary
  • Symbol
    Chdh
  • Name
    choline dehydrogenase
  • Synonyms
    D630034H06Rik, MGC:30702
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860776
    NCBI Gene: 218865
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:29730957-29762423 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 18.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860776
 protein coding gene Chr14:29730957-29762484 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021101
 protein coding gene Chr14:23113684-23145156 (+)
A/J MGP_AJ_G0021049
 protein coding gene Chr14:22242296-22273687 (+)
AKR/J MGP_AKRJ_G0021026
 protein coding gene Chr14:23335830-23367211 (+)
BALB/cJ MGP_BALBcJ_G0021053
 protein coding gene Chr14:22334849-22366426 (+)
C3H/HeJ MGP_C3HHeJ_G0020836
 protein coding gene Chr14:23196042-23227487 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021485
 protein coding gene Chr14:24032163-24063596 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019048
 protein coding gene Chr14:22313856-22347171 (+)
CAST/EiJ MGP_CASTEiJ_G0020361
 protein coding gene Chr14:22915300-22947164 (+)
CBA/J MGP_CBAJ_G0020803
 protein coding gene Chr14:24957860-24989273 (+)
DBA/2J MGP_DBA2J_G0020925
 protein coding gene Chr14:22286084-22317676 (+)
FVB/NJ MGP_FVBNJ_G0020909
 protein coding gene Chr14:22234341-22265734 (+)
LP/J MGP_LPJ_G0020994
 protein coding gene Chr14:23433265-23464708 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020935
 protein coding gene Chr14:24268641-24299992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021518
 protein coding gene Chr14:23091984-23123423 (+)
PWK/PhJ MGP_PWKPhJ_G0020109
 protein coding gene Chr14:21711312-21744300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019933
 protein coding gene Chr14:22654699-22683117 (+)
WSB/EiJ MGP_WSBEiJ_G0020416
 protein coding gene Chr14:23149689-23181103 (+)



Homology
more
  • Human Ortholog
    CHDH, choline dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHDH, choline dehydrogenase
  • Links
    NCBI Gene ID: 55349
    neXtProt AC: NX_Q8NE62
    UniProt: Q8NE62

  • Chr Location
    3p21.1; chr3:53812335-53846419 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous male mutants show reduced fertility due to reduced sperm motility caused by abnormal mitochondrial function and structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    145
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 218865 NCBI Gene Model | MGI Sequence Detail 31467 C57BL/6J ±  kb
    transcript NM_001136240 RefSeq | MGI Sequence Detail 5652 C57BL/6  
    polypeptide Q8BJ64 UniProt | EBI | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145756
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:312368 Imbard A, et al., Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Sci Rep. 2021 Oct 26;11(1):21132
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory