About   Help   FAQ
Nmu Gene Detail
Summary
  • Symbol
    Nmu
  • Name
    neuromedin U
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860476
    NCBI Gene: 56183
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76481342-76511624 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 40.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860476
 protein coding gene Chr5:76481342-76511635 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029644
 protein coding gene Chr5:76506002-76538695 (-)
A/J MGP_AJ_G0029612
 protein coding gene Chr5:73584071-73614030 (-)
AKR/J MGP_AKRJ_G0029560
 protein coding gene Chr5:75979232-76010365 (-)
BALB/cJ MGP_BALBcJ_G0029621
 protein coding gene Chr5:74332319-74362381 (-)
C3H/HeJ MGP_C3HHeJ_G0029344
 protein coding gene Chr5:76366607-76398019 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030075
 protein coding gene Chr5:79568178-79598718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027316
 protein coding gene Chr5:69238257-69268890 (-)
CAST/EiJ MGP_CASTEiJ_G0028752
 protein coding gene Chr5:75550316-75581824 (-)
CBA/J MGP_CBAJ_G0029313
 protein coding gene Chr5:82175417-82208879 (-)
DBA/2J MGP_DBA2J_G0029458
 protein coding gene Chr5:73660129-73690810 (-)
FVB/NJ MGP_FVBNJ_G0029419
 protein coding gene Chr5:72842470-72872956 (-)
LP/J MGP_LPJ_G0029545
 protein coding gene Chr5:76945958-76977515 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029447
 protein coding gene Chr5:85359284-85391893 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030108
 protein coding gene Chr5:75538426-75571282 (-)
PWK/PhJ MGP_PWKPhJ_G0028475
 protein coding gene Chr5:72667094-72699908 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028310
 protein coding gene Chr5:74896155-74933785 (-)
WSB/EiJ MGP_WSBEiJ_G0028832
 protein coding gene Chr5:75844400-75876407 (-)



Homology
more
  • Human Ortholog
    NMU, neuromedin U
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMU, neuromedin U
  • Links
    NCBI Gene ID: 10874
    neXtProt AC: NX_P48645
    UniProt: P48645

  • Chr Location
    4q12; chr4:55595229-55636793 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NMU associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are healthy and viable.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56183 NCBI Gene Model | MGI Sequence Detail 30283 C57BL/6J ±  kb
    transcript NM_019515 RefSeq | MGI Sequence Detail 828 BALB/c  
    polypeptide Q9QXK8 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:340951 Li Y, et al., Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine. Science. 2023 Sep 15;381(6663):1189-1196
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory