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Irx5 Gene Detail
Summary
  • Symbol
    Irx5
  • Name
    Iroquois homeobox 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859086
    NCBI Gene: 54352
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:93084424-93088084 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.93 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859086
 protein coding gene Chr8:93084253-93102914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033934
 protein coding gene Chr8:93648973-93654229 (+)
A/J MGP_AJ_G0033917
 protein coding gene Chr8:89960797-89964457 (+)
AKR/J MGP_AKRJ_G0033843
 protein coding gene Chr8:92497538-92501220 (+)
BALB/cJ MGP_BALBcJ_G0033909
 protein coding gene Chr8:90115814-90119765 (+)
C3H/HeJ MGP_C3HHeJ_G0033619
 protein coding gene Chr8:93193929-93197589 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034430
 protein coding gene Chr8:97089255-97092915 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031371
 protein coding gene Chr8:83887602-83891254 (+)
CAST/EiJ MGP_CASTEiJ_G0032951
 protein coding gene Chr8:92743149-92746812 (+)
CBA/J MGP_CBAJ_G0033595
 protein coding gene Chr8:100328151-100334350 (+)
DBA/2J MGP_DBA2J_G0033749
 protein coding gene Chr8:89508246-89511859 (+)
FVB/NJ MGP_FVBNJ_G0033696
 protein coding gene Chr8:88438493-88443092 (+)
LP/J MGP_LPJ_G0033841
 protein coding gene Chr8:93761819-93765285 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033738
 protein coding gene Chr8:102713972-102720111 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034448
 protein coding gene Chr8:92595806-92600365 (+)
PWK/PhJ MGP_PWKPhJ_G0032653
 protein coding gene Chr8:88846876-88864729 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032490
 protein coding gene Chr8:91463194-91466860 (+)
WSB/EiJ MGP_WSBEiJ_G0033063
 protein coding gene Chr8:93064577-93068242 (+)



Homology
more
  • Human Ortholog
    IRX5, iroquois homeobox 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRX5, iroquois homeobox 5
  • Synonyms
    HMMS, IRX-2a, IRXB2
  • Links
    NCBI Gene ID: 10265
    neXtProt AC: NX_P78411
    UniProt: P78411

  • Chr Location
    16q12.2; chr16:54930865-54934485 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body size, narrow eye opening, and impaired retinal cone bipolar cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1119
  • Tissues
    257
  • cDNA Data
    35
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54352 NCBI Gene Model | MGI Sequence Detail 3661 C57BL/6J ±  kb
    transcript NM_018826 RefSeq | MGI Sequence Detail 2421 ZRU/MplStud  
    polypeptide Q9JKQ4 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 36
      Primer pair 3
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 69
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:61328 Cohen DR, et al., Expression of two novel mouse iroquois homeobox genes during neurogenesis. Mech Dev. 2000 Mar 1;91(1-2):317-21
    • Latest
      J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory