About   Help   FAQ
Pik3cg Gene Detail
Summary
  • Symbol
    Pik3cg
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  • Synonyms
    5830428L06Rik, p110gamma, PI3Kgamma, PI(3)Kgamma, PI3Kgamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353576
    NCBI Gene: 30955
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:32223472-32258658 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.74 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353576
 protein coding gene Chr12:32223128-32258675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019669
 protein coding gene Chr12:30160177-30209487 (-)
A/J MGP_AJ_G0019636
 protein coding gene Chr12:29302316-29339445 (-)
AKR/J MGP_AKRJ_G0019607
 protein coding gene Chr12:30234805-30272100 (-)
BALB/cJ MGP_BALBcJ_G0019613
 protein coding gene Chr12:29527295-29563013 (-)
C3H/HeJ MGP_C3HHeJ_G0019417
 protein coding gene Chr12:30114026-30152767 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020060
 protein coding gene Chr12:31108090-31144088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017685
 protein coding gene Chr12:28589894-28627196 (-)
CAST/EiJ MGP_CASTEiJ_G0018972
 protein coding gene Chr12:25126496-25164883 (-)
CBA/J MGP_CBAJ_G0019389
 protein coding gene Chr12:32110370-32148346 (-)
DBA/2J MGP_DBA2J_G0019502
 protein coding gene Chr12:29128297-29162909 (-)
FVB/NJ MGP_FVBNJ_G0019493
 protein coding gene Chr12:28916392-28952698 (-)
LP/J MGP_LPJ_G0019572
 protein coding gene Chr12:30259013-30298605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019528
 protein coding gene Chr12:31745843-31783358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020100
 protein coding gene Chr12:29761972-29797713 (-)
PWK/PhJ MGP_PWKPhJ_G0018739
 protein coding gene Chr12:23879977-23918282 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018527
 protein coding gene Chr12:24356607-24397681 (-)
WSB/EiJ MGP_WSBEiJ_G0019022
 protein coding gene Chr12:29999537-30036430 (-)



Homology
more
  • Human Ortholog
    PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  • Synonyms
    IMD97, p110gamma, p120-PI3K, PI3CG, PI3K, PI3Kgamma, PIK3
  • Links
    NCBI Gene ID: 5294
    neXtProt AC: NX_P48736
    UniProt: P48736

  • Chr Location
    7q22.3; chr7:106865278-106908980 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PIK3CG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 7 alleles in 8 genetic backgrounds
    27 phenotypes from multigenic genotypes
    1 images
    191 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    95
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020573 Ensembl Gene Model | MGI Sequence Detail 35187 C57BL/6J ±  kb
    transcript ENSMUST00000156904 Ensembl | MGI Sequence Detail 4805 Not Applicable  
    polypeptide ENSMUSP00000123539 Ensembl | MGI Sequence Detail 1102 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000012722 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
      (term hierarchy)
    • EC
      2.7.1.137, 2.7.1.153, 2.7.1.154, 2.7.11.1
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR002420 C2 phosphatidylinositol 3-kinase-type domain
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR003113 Phosphatidylinositol 3-kinase, adaptor-binding domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
      IPR045580 PIK3 catalytic subunit gamma, adaptor-binding domain
      IPR011009 Protein kinase-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923289
    References
    more
    • Summaries
      All 270
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 191
    • Earliest
      J:68953 Klesse LJ, et al., p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci. 1998 Dec 15;18(24):10420-8
    • Latest
      J:313009 Zhao J, et al., ACTH treatment promotes murine cardiac allograft acceptance. JCI Insight. 2021 Jul 8;6(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory