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Limd1 Gene Detail
Summary
  • Symbol
    Limd1
  • Name
    LIM domains containing 1
  • Synonyms
    D9Ertd192e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352502
    NCBI Gene: 29806
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123307771-123350617 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 74.00 cM, cytoband F
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    429 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352502
 protein coding gene Chr9:123306790-123350617 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035477
 protein coding gene Chr9:126528576-126576280 (+)
A/J MGP_AJ_G0035458
 protein coding gene Chr9:121686104-121728944 (+)
AKR/J MGP_AKRJ_G0035391
 protein coding gene Chr9:124942921-124987677 (+)
BALB/cJ MGP_BALBcJ_G0035454
 protein coding gene Chr9:121619286-121663432 (+)
C3H/HeJ MGP_C3HHeJ_G0035161
 protein coding gene Chr9:125393111-125436862 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035977
 protein coding gene Chr9:130025352-130073365 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032859
 protein coding gene Chr9:118809791-118850404 (+)
CAST/EiJ MGP_CASTEiJ_G0034466
 protein coding gene Chr9:125432816-125476829 (+)
CBA/J MGP_CBAJ_G0035129
 protein coding gene Chr9:134759900-134808385 (+)
DBA/2J MGP_DBA2J_G0035288
 protein coding gene Chr9:121131278-121174573 (+)
FVB/NJ MGP_FVBNJ_G0035235
 protein coding gene Chr9:120036952-120075818 (+)
LP/J MGP_LPJ_G0035367
 protein coding gene Chr9:126864796-126911255 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035276
 protein coding gene Chr9:135570520-135615224 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035996
 protein coding gene Chr9:125406995-125456633 (+)
PWK/PhJ MGP_PWKPhJ_G0034170
 protein coding gene Chr9:121581674-121626807 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034007
 protein coding gene Chr9:125527066-125572928 (+)
WSB/EiJ MGP_WSBEiJ_G0034586
 protein coding gene Chr9:125252437-125295164 (+)



Homology
more
  • Human Ortholog
    LIMD1, LIM domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIMD1, LIM domain containing 1
  • Links
    NCBI Gene ID: 8994
    neXtProt AC: NX_Q9UGP4
    UniProt: Q9UGP4

  • Chr Location
    3p21.31; chr3:45555394-45686341 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal basal bone osteoclast numbers and bone density but are resistant to physiological and pathologic osteoclastogenic stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    62
  • cDNA Data
    192
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025239 Ensembl Gene Model | MGI Sequence Detail 42847 C57BL/6J ±  kb
    transcript ENSMUST00000026269 Ensembl | MGI Sequence Detail 4848 Not Applicable  
    polypeptide ENSMUSP00000026269 Ensembl | MGI Sequence Detail 668 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 196
      Genomic 1
      cDNA 192
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098702, MGI:2143352
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 8
    • Earliest
      J:59385 Kiss H, et al., A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. Hum Genet. 1999 Dec;105(6):552-9
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory