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Insl6 Gene Detail
Summary
  • Symbol
    Insl6
  • Name
    insulin-like 6
  • Synonyms
    relaxin/insulin-like factor 1, RIF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351595
    NCBI Gene: 27356
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29298754-29302718 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 23.82 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351595
 protein coding gene Chr19:29298744-29302756 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025019
 protein coding gene Chr19:27769391-27775442 (-)
A/J MGP_AJ_G0024996
 protein coding gene Chr19:26372887-26377532 (-)
AKR/J MGP_AKRJ_G0024964
 protein coding gene Chr19:27325923-27333247 (-)
BALB/cJ MGP_BALBcJ_G0024995
 protein coding gene Chr19:26421584-26425592 (-)
C3H/HeJ MGP_C3HHeJ_G0024751
 protein coding gene Chr19:27303690-27309863 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025436
 protein coding gene Chr19:28541776-28547326 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022855
 protein coding gene Chr19:26347581-26351583 (-)
CAST/EiJ MGP_CASTEiJ_G0024221
 protein coding gene Chr19:27130579-27135973 (-)
CBA/J MGP_CBAJ_G0024729
 protein coding gene Chr19:29887660-29894129 (-)
DBA/2J MGP_DBA2J_G0024861
 protein coding gene Chr19:26331454-26335554 (-)
FVB/NJ MGP_FVBNJ_G0024823
 protein coding gene Chr19:26187557-26192237 (-)
LP/J MGP_LPJ_G0024946
 protein coding gene Chr19:27768666-27779540 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024850
 protein coding gene Chr19:29836696-29840671 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025491
 protein coding gene Chr19:27347721-27352847 (-)
PWK/PhJ MGP_PWKPhJ_G0023969
 protein coding gene Chr19:26004557-26008912 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023773
 protein coding gene Chr19:26622898-26626922 (-)
WSB/EiJ MGP_WSBEiJ_G0024288
 protein coding gene Chr19:27396101-27401013 (-)



Homology
more
  • Human Ortholog
    INSL6, insulin like 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INSL6, insulin like 6
  • Synonyms
    RIF1
  • Links
    NCBI Gene ID: 11172
    neXtProt AC: NX_Q9Y581
    UniProt: Q9Y581

  • Chr Location
    9p24.1; chr9:4991976-5185647 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with male germ cell apoptosis and reduced sperm motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    23
  • cDNA Data
    26
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27356 NCBI Gene Model | MGI Sequence Detail 3965 C57BL/6J ±  kb
    transcript NM_013754 RefSeq | MGI Sequence Detail 660 FVB/N  
    polypeptide Q9QY05 UniProt | EBI | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 26
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:58920 Hsu SY, Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. Mol Endocrinol. 1999 Dec;13(12):2163-74
    • Latest
      J:325297 Maruyama S, et al., Relaxin Family Member Insulin-Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models. J Am Heart Assoc. 2018 Jun 10;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory