Ppp2r5c MGI Mouse Gene Detail - MGI:1349475 - protein phosphatase 2, regulatory subunit B', gamma

Symbol

Ppp2r5c
Name

protein phosphatase 2, regulatory subunit B', gamma
Synonyms

2610043M05Rik, 2700063L20Rik, B56/PP2A gamma, Band 8A, D12Bwg0916e, mKIAA0044

Feature Type

protein coding gene
IDs

MGI:1349475
NCBI Gene: 26931
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr12:110413554-110549496 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.56 cM, cytoband F2
Mapping Data

7 experiments

SNPs within 2kb

1276 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349475	protein coding gene	Chr12:110413532-110549509 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020117	protein coding gene	Chr12:112747517-112889642 (+)
A/J	MGP_AJ_G0020071	protein coding gene	Chr12:108411256-108508216 (+)
AKR/J	MGP_AKRJ_G0020047	protein coding gene	Chr12:111550200-111687528 (+)
BALB/cJ	MGP_BALBcJ_G0020057	protein coding gene	Chr12:108856138-108993163 (+)
C3H/HeJ	MGP_C3HHeJ_G0019859	protein coding gene	Chr12:111999242-112138076 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020502	protein coding gene	Chr12:116185587-116335844 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018114	protein coding gene	Chr12:104874274-105023481 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0019826	protein coding gene	Chr12:120727570-120880465 (+)
DBA/2J	MGP_DBA2J_G0019943	protein coding gene	Chr12:107925916-108057800 (+)
FVB/NJ	MGP_FVBNJ_G0019928	protein coding gene	Chr12:106683393-106853989 (+)
LP/J	MGP_LPJ_G0020018	protein coding gene	Chr12:112578608-112725099 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019966	protein coding gene	Chr12:123858916-124009478 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020531	protein coding gene	Chr12:111077292-111176286 (+)
PWK/PhJ	MGP_PWKPhJ_G0019160	protein coding gene	Chr12:102540667-102679449 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018964	protein coding gene	Chr12:105239832-105340047 (+)
WSB/EiJ	MGP_WSBEiJ_G0019458	protein coding gene	Chr12:111947580-112084722 (+)

Human Ortholog

PPP2R5C, protein phosphatase 2 regulatory subunit B'gamma

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP2R5C, protein phosphatase 2 regulatory subunit B'gamma
Synonyms

B56G, B56gamma, PR61G
Links

HGNC:9311

NCBI Gene ID: 5527

neXtProt AC: NX_Q13362

UniProt: Q13362
Chr Location

14q32.31; chr14:101760573-101927992 (+) GRCh38

MGI Vertebrate Homology

Ppp2r5c stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP2R5C
Protein SuperFamily

PP2A_B56
Gene Tree

Ppp2r5c

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Phenotype Summary

40 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

404
Endonuclease-mediated

2
Gene trapped

402
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene-trapped allele show partial neonatal lethality, hypoactivity, and abnormal ventricular septum formation associated with increased fetal cardiomyocyte apoptosis. Surviving homozygotes develop obesity and show an abnormal gait, decreased grip strength, and impaired balance.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

95
cDNA Data

24
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp2r5c

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All Sequences

149
RefSeq

55
UniProt

6
CCDS

CCDS36557.1, CCDS36558.1, CCDS88403.1, CCDS88404.1

Ensembl

ENSMUSG00000017843 (Evidence)
NCBI Gene

26931

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017843	Ensembl Gene Model \| MGI Sequence Detail	135943	C57BL/6J	± kb
transcript	ENSMUST00000084985	Ensembl \| MGI Sequence Detail	1847	Not Applicable
polypeptide	ENSMUSP00000082053	Ensembl \| MGI Sequence Detail	524	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013145 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR002554 Protein phosphatase 2A, regulatory B subunit, B56

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All nucleic 34

cDNA 28

Primer pair 6

Microarray probesets 15

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MGD-MRK-34036, MGI:106344, MGI:1917494, MGI:1922861, MGI:2144759, MGI:2145038, MGI:3034420

Summaries

All 55

Developmental Gene Expression 10

Gene Ontology 7

Phenotypes 12
Earliest

J:51733 Francia G, et al., Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression. Cancer Res. 1996 Sep 1;56(17):3855-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp2r5c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115199	Chr12:110413522-110413557 (+)	-14 bp
Tssr115200	Chr12:110413585-110413622 (+)	50 bp
Tssr115201	Chr12:110413636-110413641 (+)	85 bp
Tssr115202	Chr12:110413646-110413664 (+)	101 bp
Tssr115203	Chr12:110413677-110413693 (+)	131 bp
Tssr115204	Chr12:110427194-110427207 (+)	13,647 bp
Tssr115205	Chr12:110430335-110430348 (+)	16,788 bp
Tssr115206	Chr12:110430353-110430366 (+)	16,806 bp
Tssr115207	Chr12:110450454-110450472 (+)	36,909 bp
Tssr115208	Chr12:110450484-110450511 (+)	36,944 bp
Tssr115209	Chr12:110450529-110450538 (+)	36,980 bp
Tssr115210	Chr12:110452144-110452189 (+)	38,613 bp
Tssr115211	Chr12:110452223-110452240 (+)	38,678 bp
Tssr115212	Chr12:110452746-110452767 (+)	39,203 bp
Tssr115213	Chr12:110464048-110464060 (+)	50,500 bp
Tssr115214	Chr12:110464080-110464122 (+)	50,547 bp
Tssr115215	Chr12:110465849-110465902 (+)	52,322 bp
Tssr115216	Chr12:110467238-110467242 (+)	53,686 bp
Tssr115217	Chr12:110482642-110482647 (+)	69,091 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23