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Haao Gene Detail
Summary
  • Symbol
    Haao
  • Name
    3-hydroxyanthranilate 3,4-dioxygenase
  • Synonyms
    0610007K21Rik, 0610012J07Rik, 3HAO, 3-HAO, 3-HAOxase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349444
    NCBI Gene: 107766
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:84138585-84155392 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 54.85 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349444
 protein coding gene Chr17:84138585-84157589 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024076
 protein coding gene Chr17:86942261-86960418 (-)
A/J MGP_AJ_G0024035
 protein coding gene Chr17:84208374-84225034 (-)
AKR/J MGP_AKRJ_G0024004
 protein coding gene Chr17:85562439-85579810 (-)
BALB/cJ MGP_BALBcJ_G0024036
 protein coding gene Chr17:84064947-84080089 (-)
C3H/HeJ MGP_C3HHeJ_G0023801
 protein coding gene Chr17:86416683-86433174 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024481
 protein coding gene Chr17:90059031-90075594 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021920
 protein coding gene Chr17:79419810-79435439 (-)
CAST/EiJ MGP_CASTEiJ_G0023280
 protein coding gene Chr17:87156668-87174797 (-)
CBA/J MGP_CBAJ_G0023775
 protein coding gene Chr17:93766814-93785617 (-)
DBA/2J MGP_DBA2J_G0023903
 protein coding gene Chr17:82696907-82712201 (-)
FVB/NJ MGP_FVBNJ_G0023869
 protein coding gene Chr17:82174021-82189936 (-)
LP/J MGP_LPJ_G0023987
 protein coding gene Chr17:87693456-87713031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023897
 protein coding gene Chr17:93904606-93919969 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024526
 protein coding gene Chr17:86063118-86079427 (-)
PWK/PhJ MGP_PWKPhJ_G0023025
 protein coding gene Chr17:82249002-82266408 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022836
 protein coding gene Chr17:82839497-82854862 (-)
WSB/EiJ MGP_WSBEiJ_G0023347
 protein coding gene Chr17:86910142-86928438 (-)



Homology
more
  • Human Ortholog
    HAAO, 3-hydroxyanthranilate 3,4-dioxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAAO, 3-hydroxyanthranilate 3,4-dioxygenase
  • Synonyms
    3-HAO, h3HAO, HAO, VCRL1
  • Links
    NCBI Gene ID: 23498
    neXtProt AC: NX_P46952
    UniProt: P46952

  • Chr Location
    2p21; chr2:42767089-42792593 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced LPS-induced depressive behaviors and altered kynurenine metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    99
  • cDNA Data
    96
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000673 Ensembl Gene Model | MGI Sequence Detail 16808 C57BL/6J ±  kb
    transcript ENSMUST00000000687 Ensembl | MGI Sequence Detail 1381 Not Applicable  
    polypeptide ENSMUSP00000000687 Ensembl | MGI Sequence Detail 286 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 2
      cDNA 96

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913307, MGI:1918919
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:131587 Nakano K, et al., Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Brain Res. 1992 Feb 14;572(1-2):1-4
    • Latest
      J:332046 Maganin AG, et al., Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice. J Clin Invest. 2022 Dec 1;132(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory