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Snf8 Gene Detail
Summary
  • Symbol
    Snf8
  • Name
    SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
  • Synonyms
    D11Moh34, MGC:7335
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343161
    NCBI Gene: 27681
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95925711-95938256 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343161
 protein coding gene Chr11:95925711-95938256 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018995
 protein coding gene Chr11:98310154-98322525 (+)
A/J MGP_AJ_G0018963
 protein coding gene Chr11:94313671-94327255 (+)
AKR/J MGP_AKRJ_G0018933
 protein coding gene Chr11:97219090-97232667 (+)
BALB/cJ MGP_BALBcJ_G0018936
 protein coding gene Chr11:94797282-94809964 (+)
C3H/HeJ MGP_C3HHeJ_G0018750
 protein coding gene Chr11:97361019-97372982 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019388
 protein coding gene Chr11:101377007-101399353 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017018
 protein coding gene Chr11:91800809-91812842 (+)
CAST/EiJ MGP_CASTEiJ_G0018304
 protein coding gene Chr11:98174769-98187644 (+)
CBA/J MGP_CBAJ_G0018721
 protein coding gene Chr11:105532829-105545035 (+)
DBA/2J MGP_DBA2J_G0018829
 protein coding gene Chr11:93884513-93896915 (+)
FVB/NJ MGP_FVBNJ_G0018818
 protein coding gene Chr11:93359181-93372389 (+)
LP/J MGP_LPJ_G0018899
 protein coding gene Chr11:98862028-98876170 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018845
 protein coding gene Chr11:105529322-105547048 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019428
 protein coding gene Chr11:97519272-97532375 (+)
PWK/PhJ MGP_PWKPhJ_G0018075
 protein coding gene Chr11:94827004-94839899 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017864
 protein coding gene Chr11:97223721-97241090 (+)
WSB/EiJ MGP_WSBEiJ_G0018353
 protein coding gene Chr11:97418437-97432707 (+)



Homology
more
  • Human Ortholog
    SNF8, SNF8 subunit of ESCRT-II
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNF8, SNF8 subunit of ESCRT-II
  • Synonyms
    Dot3, EAP30, VPS22
  • Links
    NCBI Gene ID: 11267
    neXtProt AC: NX_Q96H20
    UniProt: Q96H20

  • Chr Location
    17q21.32; chr17:48929316-48944842 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    31
  • cDNA Data
    93
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27681 NCBI Gene Model | MGI Sequence Detail 12546 C57BL/6J ±  kb
    transcript NR_189310 RefSeq | MGI Sequence Detail 993 C57BL/6  
    polypeptide Q9CZ28 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 12
      cDNA 93
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
    • Latest
      J:339600 Hermosilla Aguayo V, et al., ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling. Dev Biol. 2023 Aug 10;503:25-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory