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Dazl Gene Detail
Summary
  • Symbol
    Dazl
  • Name
    deleted in azoospermia-like
  • Synonyms
    Dazla, Daz-like, Tpx2, Tpx-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342328
    NCBI Gene: 13164
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:50586422-50600627 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 25.86 cM, cytoband B1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342328
 protein coding gene Chr17:50586422-50600664 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023881
 protein coding gene Chr17:51691160-51705355 (-)
A/J MGP_AJ_G0023841
 protein coding gene Chr17:50292049-50306244 (-)
AKR/J MGP_AKRJ_G0023809
 protein coding gene Chr17:50850823-50865018 (-)
BALB/cJ MGP_BALBcJ_G0023843
 protein coding gene Chr17:50202698-50216893 (-)
C3H/HeJ MGP_C3HHeJ_G0023606
 protein coding gene Chr17:51540461-51554656 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024286
 protein coding gene Chr17:53771960-53786165 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021735
 protein coding gene Chr17:47003765-47017724 (-)
CAST/EiJ MGP_CASTEiJ_G0023088
 protein coding gene Chr17:51773927-51788128 (-)
CBA/J MGP_CBAJ_G0023582
 protein coding gene Chr17:55790015-55804235 (-)
DBA/2J MGP_DBA2J_G0023711
 protein coding gene Chr17:49044375-49058803 (-)
FVB/NJ MGP_FVBNJ_G0023677
 protein coding gene Chr17:48737261-48751457 (-)
LP/J MGP_LPJ_G0023791
 protein coding gene Chr17:52398002-52413036 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023705
 protein coding gene Chr17:55129479-55159723 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024332
 protein coding gene Chr17:51163605-51177809 (-)
PWK/PhJ MGP_PWKPhJ_G0022833
 protein coding gene Chr17:48496366-48510669 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022647
 protein coding gene Chr17:48101849-48115979 (-)
WSB/EiJ MGP_WSBEiJ_G0023152
 protein coding gene Chr17:51771934-51788542 (-)



Homology
more
  • Human Ortholog
    DAZ1, deleted in azoospermia 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAZ1, deleted in azoospermia 1
  • Synonyms
    DAZ, SPGY
  • Links
    NCBI Gene ID: 1617
    neXtProt AC: NX_Q9NQZ3
    UniProt: Q9NQZ3

  • Chr Location
    Yq11.223; chrY:23129355-23199094 (-)  GRCh38
  • Human Ortholog
    DAZ2, deleted in azoospermia 2
  • Synonyms
    pDP1678
  • Links
    NCBI Gene ID: 57055
    neXtProt AC: NX_Q13117
    UniProt: Q13117

  • Chr Location
    Yq11.223; chrY:23219447-23291356 (+)  GRCh38
  • Human Ortholog
    DAZ3, deleted in azoospermia 3
  • Synonyms
    pDP1679
  • Links
    NCBI Gene ID: 57054
    neXtProt AC: NX_Q9NR90
    UniProt: Q9NR90

  • Chr Location
    Yq11.23; chrY:24763069-24813492 (-)  GRCh38
  • Human Ortholog
    DAZ4, deleted in azoospermia 4
  • Synonyms
    pDP1680, pDP1681
  • Links
    NCBI Gene ID: 57135
    neXtProt AC: NX_Q86SG3
    UniProt: Q86SG3

  • Chr Location
    Yq11.23; chrY:24833820-24907040 (+)  GRCh38
  • Human Ortholog
    DAZL, deleted in azoospermia like
  • Synonyms
    DAZH, DAZL1, DAZLA, SPGYLA
  • Links
    NCBI Gene ID: 1618
    neXtProt AC: NX_Q92904
    UniProt: Q92904

  • Chr Location
    3p24.3; chr3:16586792-16670306 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation exhibit sterility with a complete absence of mature germ cells. In mutants, few spermatogonia enter meiosis, and those that do fail to proceed beyond pachytene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    942
  • Tissues
    73
  • cDNA Data
    469
  • Literature Summary
    70
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13164 NCBI Gene Model | MGI Sequence Detail 14206 C57BL/6J ±  kb
    transcript NM_010021 RefSeq | MGI Sequence Detail 2942 ZRU/MplStud  
    polypeptide Q64368 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 496
      Genomic 4
      cDNA 472
      Primer pair 17
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15212, MGD-MRK-15214, MGD-MRK-35375, MGI:106914, MGI:98816
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 70
      Gene Ontology 15
      Phenotypes 41
    • Earliest
      J:11372 Kasahara M, et al., Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17. Immunogenetics. 1991;34(2):132-5
    • Latest
      J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory