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Sec22b Gene Detail
Summary
  • Symbol
    Sec22b
  • Name
    SEC22 homolog B, vesicle trafficking protein
  • Synonyms
    4930564D15Rik, ERS-24, Sec22l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338759
    NCBI Gene: 20333
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:97808543-97829634 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338759
 protein coding gene Chr3:97808506-97830592 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027646
 protein coding gene Chr3:98873490-98897029 (+)
A/J MGP_AJ_G0027608
 protein coding gene Chr3:95703748-95725835 (+)
AKR/J MGP_AKRJ_G0027575
 protein coding gene Chr3:97997084-98019164 (+)
BALB/cJ MGP_BALBcJ_G0027618
 protein coding gene Chr3:95507382-95529463 (+)
C3H/HeJ MGP_C3HHeJ_G0027350
 protein coding gene Chr3:98267764-98289854 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028064
 protein coding gene Chr3:102546848-102568922 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025406
 protein coding gene Chr3:91961941-91984019 (+)
CAST/EiJ MGP_CASTEiJ_G0026805
 protein coding gene Chr3:97564450-97586646 (+)
CBA/J MGP_CBAJ_G0027325
 protein coding gene Chr3:106200239-106222325 (+)
DBA/2J MGP_DBA2J_G0027468
 protein coding gene Chr3:95016033-95038866 (+)
FVB/NJ MGP_FVBNJ_G0027437
 protein coding gene Chr3:93009126-93031188 (+)
LP/J MGP_LPJ_G0027573
 protein coding gene Chr3:100131380-100154385 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027463
 protein coding gene Chr3:112282186-112304315 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028118
 protein coding gene Chr3:97622195-97644271 (+)
PWK/PhJ MGP_PWKPhJ_G0026530
 protein coding gene Chr3:94905313-94927598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026352
 protein coding gene Chr3:95901533-95923589 (+)
WSB/EiJ MGP_WSBEiJ_G0026883
 protein coding gene Chr3:98061519-98083606 (+)



Homology
more
  • Human Ortholog
    SEC22B, SEC22 homolog B, vesicle trafficking protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC22B, SEC22 homolog B, vesicle trafficking protein
  • Synonyms
    ERS-24, SEC22L1
  • Links
    NCBI Gene ID: 9554
    neXtProt AC: NX_O75396
    UniProt: O75396

  • Chr Location
    1p12; chr1:120150898-120176520 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Sec22b
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    15 strains or lines available
Homozygous knockout has no effect on the development or function of lymphoid cells, nor on the process of antigen cross-presentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    18
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20333 NCBI Gene Model | MGI Sequence Detail 21092 C57BL/6J ±  kb
transcript NM_011342 RefSeq | MGI Sequence Detail 1815 C57BL/6  
polypeptide O08547 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 6
Other
Accession IDs
less
MGI:1922615, MGI:2139737, MGI:2140084, MGI:3035211
References
more
  • Summaries
    All 50
    Diseases 1
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:46012 Hay JC, et al., Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997 Apr 4;89(1):149-58
  • Latest
    J:337822 Bonaud A, et al., Sec22b is a critical and nonredundant regulator of plasma cell maintenance. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2213056120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory