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Hint1 Gene Detail
Summary
  • Symbol
    Hint1
  • Name
    histidine triad nucleotide binding protein 1
  • Synonyms
    Ipk1, PKCI-1, PKC inhibitor/ interacting protein, PRKCNH1, protein kinase C inhibitor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321133
    NCBI Gene: 15254
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54757209-54761327 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321133
 protein coding gene Chr11:54757209-54761332 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018320
 protein coding gene Chr11:54354058-54358179 (+)
A/J MGP_AJ_G0018289
 protein coding gene Chr11:52328949-52333067 (+)
AKR/J MGP_AKRJ_G0018258
 protein coding gene Chr11:54048283-54052401 (+)
BALB/cJ MGP_BALBcJ_G0018260
 protein coding gene Chr11:52674765-52678881 (+)
C3H/HeJ MGP_C3HHeJ_G0018071
 protein coding gene Chr11:53980485-53984607 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018712
 protein coding gene Chr11:56015565-56019676 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016362
 protein coding gene Chr11:49765958-49770260 (+)
CAST/EiJ MGP_CASTEiJ_G0017636
 protein coding gene Chr11:54025760-54029877 (+)
CBA/J MGP_CBAJ_G0018046
 protein coding gene Chr11:58670368-58674479 (+)
DBA/2J MGP_DBA2J_G0018155
 protein coding gene Chr11:52035800-52039918 (+)
FVB/NJ MGP_FVBNJ_G0018147
 protein coding gene Chr11:51691420-51695534 (+)
LP/J MGP_LPJ_G0018230
 protein coding gene Chr11:54808598-54812712 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018173
 protein coding gene Chr11:59885723-59891093 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018754
 protein coding gene Chr11:54057857-54061961 (+)
PWK/PhJ MGP_PWKPhJ_G0017409
 protein coding gene Chr11:52579869-52583993 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017204
 protein coding gene Chr11:53851374-53855522 (+)
WSB/EiJ MGP_WSBEiJ_G0017684
 protein coding gene Chr11:53694929-53699041 (+)



Homology
more
  • Human Ortholog
    HINT1, histidine triad nucleotide binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HINT1, histidine triad nucleotide binding protein 1
  • Synonyms
    HINT, NMAN, PKCI-1, PRKCNH1
  • Links
    NCBI Gene ID: 3094
    neXtProt AC: NX_P49773
    UniProt: P49773

  • Chr Location
    5q23.3; chr5:131155383-131224468 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HINT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals do not exhibit an overt phenotype, though one line of mutant mice was shown to be more susceptible to carcinogen-induced tumors than wild-type.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    38
  • cDNA Data
    150
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020267 Ensembl Gene Model | MGI Sequence Detail 4119 C57BL/6J ±  kb
    transcript ENSMUST00000020504 Ensembl | MGI Sequence Detail 636 Not Applicable  
    polypeptide ENSMUSP00000020504 Ensembl | MGI Sequence Detail 126 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      cDNA 151
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144040
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345292 Takahashi S, et al., USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage. Biochem Biophys Res Commun. 2022 Jul 23;614:198-206
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory