About   Help   FAQ
Traip Gene Detail
Summary
  • Symbol
    Traip
  • Name
    TRAF-interacting protein
  • Synonyms
    Trip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096377
    NCBI Gene: 22036
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107828158-107849469 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096377
 protein coding gene Chr9:107827335-107849469 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035275
 protein coding gene Chr9:109865077-109887208 (+)
A/J MGP_AJ_G0035254
 protein coding gene Chr9:105854277-105876348 (+)
AKR/J MGP_AKRJ_G0035186
 protein coding gene Chr9:108495106-108517240 (+)
BALB/cJ MGP_BALBcJ_G0035248
 protein coding gene Chr9:105524663-105546735 (+)
C3H/HeJ MGP_C3HHeJ_G0034958
 protein coding gene Chr9:108892836-108914905 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035768
 protein coding gene Chr9:112837960-112860099 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032666
 protein coding gene Chr9:103287287-103309769 (+)
CAST/EiJ MGP_CASTEiJ_G0034269
 protein coding gene Chr9:108849051-108871284 (+)
CBA/J MGP_CBAJ_G0034926
 protein coding gene Chr9:116831781-116858905 (+)
DBA/2J MGP_DBA2J_G0035087
 protein coding gene Chr9:105308763-105330895 (+)
FVB/NJ MGP_FVBNJ_G0035035
 protein coding gene Chr9:104075002-104097143 (+)
LP/J MGP_LPJ_G0035163
 protein coding gene Chr9:110060500-110082631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035074
 protein coding gene Chr9:118428606-118451581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035789
 protein coding gene Chr9:108771429-108793559 (+)
PWK/PhJ MGP_PWKPhJ_G0033976
 protein coding gene Chr9:105630798-105653082 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033811
 protein coding gene Chr9:108835068-108857310 (+)
WSB/EiJ MGP_WSBEiJ_G0034390
 protein coding gene Chr9:108652949-108675099 (+)



Homology
more
  • Human Ortholog
    TRAIP, TRAF interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAIP, TRAF interacting protein
  • Synonyms
    RNF206, SCKL9, TRIP
  • Links
    NCBI Gene ID: 10293
    neXtProt AC: NX_Q9BWF2
    UniProt: Q9BWF2

  • Chr Location
    3p21.31; chr3:49828601-49856574 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRAIP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality at prior to E8.5, embryonic growth retardation, decreased embryonic size, decreased cell proliferation and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    39
  • cDNA Data
    33
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22036 NCBI Gene Model | MGI Sequence Detail 21312 C57BL/6J ±  kb
    transcript NM_001410472 RefSeq | MGI Sequence Detail 3038 ZRU/MplStud  
    polypeptide Q8VIG6 UniProt | EBI | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 1
      cDNA 34
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 4
    • Earliest
      J:39150 Logue SF, et al., Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Behav Neurosci. 1997 Feb;111(1):104-13
    • Latest
      J:219064 Zhang M, et al., TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J Exp Med. 2012 Sep 24;209(10):1703-11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/30/2024
    MGI 6.23     		The Jackson Laboratory