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Ing4 Gene Detail
Summary
  • Symbol
    Ing4
  • Name
    inhibitor of growth family, member 4
  • Synonyms
    D6Wsu147e, D6Xrf92, p29ING4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107307
    NCBI Gene: 28019
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125016811-125026228 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107307
 protein coding gene Chr6:125016723-125026228 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031282
 protein coding gene Chr6:128364015-128374746 (+)
A/J MGP_AJ_G0031252
 protein coding gene Chr6:123521890-123531811 (+)
AKR/J MGP_AKRJ_G0031180
 protein coding gene Chr6:126897678-126907882 (+)
BALB/cJ MGP_BALBcJ_G0031260
 protein coding gene Chr6:123119229-123128516 (+)
C3H/HeJ MGP_C3HHeJ_G0030983
 protein coding gene Chr6:126952480-126962114 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031716
 protein coding gene Chr6:131743527-131752948 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028866
 protein coding gene Chr6:120727867-120736633 (+)
CAST/EiJ MGP_CASTEiJ_G0030364
 protein coding gene Chr6:127158910-127169213 (+)
CBA/J MGP_CBAJ_G0030944
 protein coding gene Chr6:136783271-136796064 (+)
DBA/2J MGP_DBA2J_G0031100
 protein coding gene Chr6:122453908-122463078 (+)
FVB/NJ MGP_FVBNJ_G0031050
 protein coding gene Chr6:121360079-121369517 (+)
LP/J MGP_LPJ_G0031180
 protein coding gene Chr6:128526962-128536461 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031088
 protein coding gene Chr6:140831510-140843797 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031751
 protein coding gene Chr6:126789319-126798461 (+)
PWK/PhJ MGP_PWKPhJ_G0030079
 protein coding gene Chr6:120693272-120702572 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029908
 protein coding gene Chr6:124872669-124881481 (+)
WSB/EiJ MGP_WSBEiJ_G0030449
 protein coding gene Chr6:127157604-127167565 (+)



Homology
more
  • Human Ortholog
    ING4, inhibitor of growth family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ING4, inhibitor of growth family member 4
  • Synonyms
    my036, p29ING4
  • Links
    NCBI Gene ID: 51147
    neXtProt AC: NX_Q9UNL4
    UniProt: Q9UNL4

  • Chr Location
    12p13.31; chr12:6650301-6663142 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele are hypersensitive to LPS challenge and exhibit elevated cytokine responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    96
  • cDNA Data
    167
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28019 NCBI Gene Model | MGI Sequence Detail 9418 C57BL/6J ±  kb
    transcript NM_001368695 RefSeq | MGI Sequence Detail 1621 ZRU/MplStud  
    polypeptide Q8C0D7 UniProt | EBI | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 171
      cDNA 168
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32273, MGD-MRK-35773, MGI:105232
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 7
    • Earliest
      J:31523 Bassett DE Jr, et al., Comparative genomics, genome cross-referencing and XREFdb. Trends Genet. 1995 Sep;11(9):372-3
    • Latest
      J:346139 Mah SYY, et al., ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development. 2024 Mar 1;151(5):dev202617
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/30/2024
    MGI 6.23     		The Jackson Laboratory