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En1 Gene Detail
Summary
  • Symbol
    En1
  • Name
    engrailed 1
  • Synonyms
    En-1, engrailed-1, Mo-en.1
Location &
Maps
more
  • Sequence Map
    Chr1:120530246-120535719 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.74 cM, cytoband C2-qter
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95389
 protein coding gene Chr1:120530147-120535721 (+)
129S1/SvImJ ENSMUSG00200001692
 protein coding gene Chr1:118012673-118018262 (+)
A/J ENSMUSG00195004074
 protein coding gene Chr1:117253547-117259136 (+)
AKR/J ENSMUSG00220024976
 protein coding gene Chr1:117069324-117074909 (+)
BALB/cJ ENSMUSG00180012429
 protein coding gene Chr1:117665465-117671035 (+)
C3H/HeJ ENSMUSG00175018636
 protein coding gene Chr1:117484554-117490140 (+)
C57BL/6NJ ENSMUSG00215009815
 protein coding gene Chr1:117437402-117442973 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014525
 protein coding gene Chr1:112626403-112632011 (+)
CAST/EiJ ENSTCUG00005006020
 protein coding gene Chr1:116416243-116421829 (+)
CBA/J ENSMUSG00210001046
 protein coding gene Chr1:117313932-117319515 (+)
DBA/2J ENSMUSG00185013361
 protein coding gene Chr1:121757748-121763335 (+)
FVB/NJ ENSMUSG00205011721
 protein coding gene Chr1:116812937-116818523 (+)
JF1/MsJ ENSUMUG00000027456
 protein coding gene Chr1:120856413-120862036 (+)
LP/J ENSMUSG00230008492
 protein coding gene Chr1:121190408-121195991 (+)
NOD/ShiLtJ ENSMUSG00190005989
 protein coding gene Chr1:117299094-117304679 (+)
NZO/HlLtJ ENSMUSG00225004242
 protein coding gene Chr1:124967543-124973135 (+)
PWK/PhJ ENSLUMG00010014147
 protein coding gene Chr1:116464553-116470156 (+)
SPRET/EiJ ENSMSPG00010016409
 protein coding gene Chr1:119077941-119083555 (+)
WSB/EiJ ENSIUOG00005002762
 protein coding gene Chr1:117154066-117159647 (+)



Homology
more
  • Human Ortholog
    EN1, engrailed homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EN1, engrailed homeobox 1
  • Synonyms
    ENDOVESLB
  • Links
    NCBI Gene ID: 2019
    UniProt: Q05925

  • Chr Location
    2q14.2; chr2:118842171-118847648 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with En1 mouse models; 1 with human EN1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    115 phenotypes from 15 alleles in 18 genetic backgrounds
    143 phenotypes from multigenic genotypes
    1 images
    303 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes usually die within 24 hours of birth. Mutants exhibit nervous system defects, including a lack of most of the colliculi, cerebellum, and the third and fourth cranial nerves in some lines. Skeletal anomalies have also been described.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1941
  • Tissues
    464
  • cDNA Data
    34
  • Literature Summary
    338
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13798 NCBI Gene Model | MGI Sequence Detail 5474 C57BL/6J ±  kb
    transcript NM_010133 RefSeq | MGI Sequence Detail 2523 C57BL/6  
    polypeptide P09065 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 6
      cDNA 36
      Primer pair 20
      Other 48
      Antibodies 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12340, MGD-MRK-9497, MGD-MRK-9499
    References
    more
    • Summaries
      All 652
      Developmental Gene Expression 338
      Diseases 3
      Gene Ontology 19
      Phenotypes 303
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:387871 Hawkins MB, et al., The origin and evolution of dorsal determination mechanisms in vertebrate paired appendages. Curr Biol. 2026 Jun 19;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory