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Bach1 Gene Detail
Summary
  • Symbol
    Bach1
  • Name
    BTB and CNC homology 1, basic leucine zipper transcription factor 1
  • Synonyms
    6230421P05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894680
    NCBI Gene: 12013
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87495842-87530234 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1281 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894680
 protein coding gene Chr16:87495833-87530234 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022981
 protein coding gene Chr16:88441251-88477032 (+)
A/J MGP_AJ_G0022949
 protein coding gene Chr16:84355167-84390753 (+)
AKR/J MGP_AKRJ_G0022919
 protein coding gene Chr16:86921802-86956249 (+)
BALB/cJ MGP_BALBcJ_G0022951
 protein coding gene Chr16:84887105-84922213 (+)
C3H/HeJ MGP_C3HHeJ_G0022713
 protein coding gene Chr16:87493202-87527390 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023398
 protein coding gene Chr16:91300378-91343449 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020902
 protein coding gene Chr16:82206267-82240667 (+)
CAST/EiJ MGP_CASTEiJ_G0022235
 protein coding gene Chr16:87873475-87913995 (+)
CBA/J MGP_CBAJ_G0022682
 protein coding gene Chr16:95216852-95254477 (+)
DBA/2J MGP_DBA2J_G0022816
 protein coding gene Chr16:84279969-84314491 (+)
FVB/NJ MGP_FVBNJ_G0022791
 protein coding gene Chr16:83385853-83419881 (+)
LP/J MGP_LPJ_G0022885
 protein coding gene Chr16:88121770-88159037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022810
 protein coding gene Chr16:99773263-99810678 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023416
 protein coding gene Chr16:87400419-87436201 (+)
PWK/PhJ MGP_PWKPhJ_G0021978
 protein coding gene Chr16:84400448-84434286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021808
 protein coding gene Chr16:86938627-86972359 (+)
WSB/EiJ MGP_WSBEiJ_G0022283
 protein coding gene Chr16:87626554-87667317 (+)



Homology
more
  • Human Ortholog
    BACH1, BTB domain and CNC homolog 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BACH1, BTB domain and CNC homolog 1
  • Synonyms
    BACH-1, BTBD24
  • Links
    NCBI Gene ID: 571
    neXtProt AC: NX_O14867
    UniProt: O14867

  • Chr Location
    21q21.3; chr21:29194071-29630751 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are healthy and fertile with no gross abnormalities but express elevated levels of HMOX1.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    254
  • cDNA Data
    69
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12013 NCBI Gene Model | MGI Sequence Detail 34393 C57BL/6J ±  kb
    transcript NM_007520 RefSeq | MGI Sequence Detail 5858 C57BL/6  
    polypeptide P97302 UniProt | EBI | MGI Sequence Detail 739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 69
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923386, MGI:2146411
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 17
      Gene Ontology 7
      Phenotypes 47
    • Earliest
      J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory