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Lsm14b Gene Detail
Summary
  • Symbol
    Lsm14b
  • Name
    LSM family member 14B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040677
    NCBI Gene: 241846
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179666780-179677258 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 102.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040677
 protein coding gene Chr2:179666770-179677258 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026982
 protein coding gene Chr2:186522094-186532554 (+)
A/J MGP_AJ_G0026948
 protein coding gene Chr2:178861568-178872030 (+)
AKR/J MGP_AKRJ_G0026918
 protein coding gene Chr2:184212881-184223378 (+)
BALB/cJ MGP_BALBcJ_G0026957
 protein coding gene Chr2:179323699-179334163 (+)
C3H/HeJ MGP_C3HHeJ_G0026698
 protein coding gene Chr2:184570766-184581247 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027403
 protein coding gene Chr2:191915289-191925781 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024770
 protein coding gene Chr2:169553858-169564083 (+)
CAST/EiJ MGP_CASTEiJ_G0026157
 protein coding gene Chr2:182808659-182822469 (+)
CBA/J MGP_CBAJ_G0026675
 protein coding gene Chr2:198868350-198878806 (+)
DBA/2J MGP_DBA2J_G0026813
 protein coding gene Chr2:177956828-177967301 (+)
FVB/NJ MGP_FVBNJ_G0026779
 protein coding gene Chr2:176558556-176569015 (+)
LP/J MGP_LPJ_G0026914
 protein coding gene Chr2:186510340-186520866 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026798
 protein coding gene Chr2:201524251-201534713 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027462
 protein coding gene Chr2:184176244-184186723 (+)
PWK/PhJ MGP_PWKPhJ_G0025893
 protein coding gene Chr2:175467593-175478069 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025693
 protein coding gene Chr2:180671398-180681863 (+)
WSB/EiJ MGP_WSBEiJ_G0026229
 protein coding gene Chr2:185146416-185156892 (+)



Homology
more
  • Human Ortholog
    LSM14B, LSM family member 14B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LSM14B, LSM family member 14B
  • Synonyms
    bA11M20.3, C20orf40, FAM61B, FT005, LSM13, RAP55B
  • Links
    NCBI Gene ID: 149986
    UniProt: Q9BX40

  • Chr Location
    20q13.33; chr20:62122461-62135374 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female infertility and oocytes that are incompetent to complete meiosis and early embryogenesis. Male fertility is normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    17
  • cDNA Data
    33
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039108 Ensembl Gene Model | MGI Sequence Detail 10479 C57BL/6J ±  kb
    transcript ENSMUST00000055485 Ensembl | MGI Sequence Detail 2534 Not Applicable  
    polypeptide ENSMUSP00000055036 Ensembl | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 2
      cDNA 33
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 7
      Gene Ontology 1
      Phenotypes 14
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:351299 Zhang H, et al., LSM14B coordinates protein component expression in the P-body and controls oocyte maturation. J Genet Genomics. 2024 Jan;51(1):48-60
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    03/25/2025
    MGI 6.24     		The Jackson Laboratory