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Dagla Gene Detail
Summary
  • Symbol
    Dagla
  • Name
    diacylglycerol lipase, alpha
  • Synonyms
    Nsddr
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677061
    NCBI Gene: 269060
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10222629-10282241 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 6.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677061
protein coding gene Chr19:10222629-10282323 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024842
protein coding gene Chr19:7569979-7632892 (-)
A/J MGP_AJ_G0024810
protein coding gene Chr19:7052005-7111651 (-)
AKR/J MGP_AKRJ_G0024785
protein coding gene Chr19:7332357-7394002 (-)
BALB/cJ MGP_BALBcJ_G0024810
protein coding gene Chr19:7098791-7158211 (-)
C3H/HeJ MGP_C3HHeJ_G0024576
protein coding gene Chr19:7220001-7282123 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025258
protein coding gene Chr19:7923489-7984744 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022685
protein coding gene Chr19:7470097-7530382 (-)
CAST/EiJ MGP_CASTEiJ_G0024049
protein coding gene Chr19:6879687-6940600 (-)
CBA/J MGP_CBAJ_G0024550
protein coding gene Chr19:7964867-8026723 (-)
DBA/2J MGP_DBA2J_G0024677
protein coding gene Chr19:7065722-7124906 (-)
FVB/NJ MGP_FVBNJ_G0024644
protein coding gene Chr19:7104136-7163298 (-)
LP/J MGP_LPJ_G0024764
protein coding gene Chr19:7545179-7605345 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024671
protein coding gene Chr19:7870960-7929670 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025306
protein coding gene Chr19:7356145-7416047 (-)
PWK/PhJ MGP_PWKPhJ_G0023794
protein coding gene Chr19:6506347-6565727 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023599
protein coding gene Chr19:6540289-6600565 (-)
WSB/EiJ MGP_WSBEiJ_G0024111
protein coding gene Chr19:7239563-7298272 (-)



Homology
more
  • Human Ortholog
    DAGLA, diacylglycerol lipase alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAGLA, diacylglycerol lipase alpha
  • Synonyms
    C11orf11, DAGL(ALPHA), DAGLALPHA, NOC2, NSDDR
  • Links
    NCBI Gene ID: 747
    neXtProt AC: NX_Q9Y4D2
    UniProt: Q9Y4D2

  • Chr Location
    11q12.2; chr11:61680391-61747001 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human DAGLA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035735 Ensembl Gene Model | MGI Sequence Detail 59613 C57BL/6J ±  kb
    transcript ENSMUST00000039327 Ensembl | MGI Sequence Detail 5634 Not Applicable  
    polypeptide ENSMUSP00000046358 Ensembl | MGI Sequence Detail 1044 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 3
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 38
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory