About   Help   FAQ
Adamts20 Gene Detail
Summary
  • Symbol
    Adamts20
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 20
  • Synonyms
    ADAMTS-20, bt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660628
    NCBI Gene: 223838
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:94166177-94329966 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 48.20 cM
  • Mapping Data
    34 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5018 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2660628
 protein coding gene Chr15:94166177-94363299 (-)
129S1/SvImJ ENSMUSG00200034266
 protein coding gene Chr15:91307644-91434032 (-)
A/J ENSMUSG00195017449
 protein coding gene Chr15:91215556-91341957 (-)
AKR/J ENSMUSG00220026120
 protein coding gene Chr15:91266211-91392599 (-)
BALB/cJ ENSMUSG00180014777
 protein coding gene Chr15:91096609-91230736 (-)
C3H/HeJ ENSMUSG00175024040
 protein coding gene Chr15:91401833-91528383 (-)
C57BL/6NJ ENSMUSG00215016439
 protein coding gene Chr15:91204720-91335022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020194
 protein coding gene Chr15:88042327-88224348 (-)
CAST/EiJ ENSTCUG00005030051
 protein coding gene Chr15:90687598-90804927 (-)
CBA/J ENSMUSG00210013022
 protein coding gene Chr15:91183235-91309637 (-)
DBA/2J ENSMUSG00185021115
 protein coding gene Chr15:91231378-91357772 (-)
FVB/NJ ENSMUSG00205033054
 protein coding gene Chr15:90926322-91051400 (-)
JF1/MsJ ENSUMUG00000018593
 protein coding gene Chr15:90721445-90838877 (-)
LP/J ENSMUSG00230031795
 protein coding gene Chr15:94545597-94671973 (-)
NOD/ShiLtJ ENSMUSG00190023908
 protein coding gene Chr15:91225330-91364627 (-)
NZO/HlLtJ ENSMUSG00225042360
 protein coding gene Chr15:94848843-94975293 (-)
PWK/PhJ ENSLUMG00010033250
 protein coding gene Chr15:90883373-91009764 (-)
SPRET/EiJ ENSMSPG00010035727
 protein coding gene Chr15:92688877-92805593 (-)
WSB/EiJ ENSIUOG00005010832
 protein coding gene Chr15:91302228-91421308 (-)



Homology
more
  • Human Ortholog
    ADAMTS20, ADAM metallopeptidase with thrombospondin type 1 motif 20
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS20, ADAM metallopeptidase with thrombospondin type 1 motif 20
  • Synonyms
    ADAM-TS20, ADAMTS-20, GON-1
  • Links
    NCBI Gene ID: 80070
    UniProt: P59510

  • Chr Location
    12q12; chr12:43352763-43552203 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 22 alleles in 23 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for spontaneous or ENU-induced mutations exhibit abnormal coat/hair pigmentation, including a typical white belt phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    29
  • cDNA Data
    16
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223838 NCBI Gene Model | MGI Sequence Detail 163790 C57BL/6J ±  kb
    transcript NM_177431 RefSeq | MGI Sequence Detail 7938 ZRU/MplStud  
    polypeptide P59511 UniProt | EBI | MGI Sequence Detail 1906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1678, MGI:88212
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 9
      Phenotypes 57
    • Earliest
      J:283 Murray JM, et al., Belted, a new sixth chromosome mutation in the mouse. J Hered. 1945;36(9):266-8
    • Latest
      J:388025 Opoku G, et al., ADAMTS1 Is Required for Ventral Abdominal Wall Closure. J Histochem Cytochem. 2026 Apr 28;:221554261438169
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory