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Pik3c3 Gene Detail
Summary
  • Symbol
    Pik3c3
  • Name
    phosphatidylinositol 3-kinase catalytic subunit type 3
  • Synonyms
    5330434F23Rik, Vps34
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445019
    NCBI Gene: 225326
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:30405800-30481179 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 17.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445019
protein coding gene Chr18:30390441-30481179 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024210
protein coding gene Chr18:28310329-28395486 (+)
A/J MGP_AJ_G0024175
protein coding gene Chr18:27390216-27466210 (+)
AKR/J MGP_AKRJ_G0024144
protein coding gene Chr18:28138996-28215755 (+)
BALB/cJ MGP_BALBcJ_G0024175
protein coding gene Chr18:27469823-27550057 (+)
C3H/HeJ MGP_C3HHeJ_G0023943
protein coding gene Chr18:28159184-28238270 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024617
protein coding gene Chr18:29324105-29405114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022059
protein coding gene Chr18:27664029-27742066 (+)
CAST/EiJ MGP_CASTEiJ_G0023417
protein coding gene Chr18:28011774-28110009 (+)
CBA/J MGP_CBAJ_G0023911
protein coding gene Chr18:30239889-30317437 (+)
DBA/2J MGP_DBA2J_G0024043
protein coding gene Chr18:27065705-27141537 (+)
FVB/NJ MGP_FVBNJ_G0024009
protein coding gene Chr18:26788733-26864274 (+)
LP/J MGP_LPJ_G0024124
protein coding gene Chr18:28423285-28498837 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024037
protein coding gene Chr18:31531063-31621280 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024665
protein coding gene Chr18:28001552-28080825 (+)
PWK/PhJ MGP_PWKPhJ_G0023161
protein coding gene Chr18:27203988-27281610 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022970
protein coding gene Chr18:28226337-28323576 (+)
WSB/EiJ MGP_WSBEiJ_G0023481
protein coding gene Chr18:27884784-27962412 (+)



Homology
more
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
  • Synonyms
    hVps34, Vps34, VPS34
  • Links
    NCBI Gene ID: 5289
    neXtProt AC: NX_Q8NEB9
    UniProt: Q8NEB9

  • Chr Location
    18q12.3; chr18:41955234-42087830 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 6 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    8 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality between implantation and placentation, arrest prior to gastrulation, and show reduced cell proliferation. Mice homozygous for a conditional allele activated in T cells exhibit impaired naive Tcell homeostasis and mitophagy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033628 Ensembl Gene Model | MGI Sequence Detail 75380 C57BL/6J ±  kb
    transcript ENSMUST00000115812 Ensembl | MGI Sequence Detail 3257 Not Applicable  
    polypeptide ENSMUSP00000111479 Ensembl | MGI Sequence Detail 887 Not Applicable  
    For the selected sequence
    Protein
    Information
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    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012718 phosphatidylinositol 3-kinase catalytic subunit type 3
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR002420 C2 phosphatidylinositol 3-kinase-type domain
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
      IPR011009 Protein kinase-like domain superfamily
    • GlyGen
      Q6PF93 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 102
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 6
      Gene Ontology 22
      Phenotypes 36
    • Earliest
      J:33394 Virbasius JV, et al., Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13304-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory