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Nyap2 Gene Detail
Summary
  • Symbol
    Nyap2
  • Name
    neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
  • Synonyms
    9430031J16Rik, Jr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443135
    NCBI Gene: 241134
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:81054667-81319479 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 41.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6884 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443135
 protein coding gene Chr1:81054239-81345438 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016212
 protein coding gene Chr1:81933906-82220852 (+)
A/J MGP_AJ_G0016195
 protein coding gene Chr1:79035725-79311114 (+)
AKR/J MGP_AKRJ_G0016152
 protein coding gene Chr1:81187396-81462888 (+)
BALB/cJ MGP_BALBcJ_G0016150
 protein coding gene Chr1:79102432-79383814 (+)
C3H/HeJ MGP_C3HHeJ_G0015980
 protein coding gene Chr1:81550660-81840530 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016603
 protein coding gene Chr1:85108619-85400364 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014323
 protein coding gene Chr1:74322878-74588635 (+)
CAST/EiJ MGP_CASTEiJ_G0015566
 protein coding gene Chr1:80937047-81251092 (+)
CBA/J MGP_CBAJ_G0015954
 protein coding gene Chr1:87835300-88138457 (+)
DBA/2J MGP_DBA2J_G0016055
 protein coding gene Chr1:78327601-78596077 (+)
FVB/NJ MGP_FVBNJ_G0016058
 protein coding gene Chr1:77455638-77724111 (+)
LP/J MGP_LPJ_G0016128
 protein coding gene Chr1:83068623-83357119 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016078
 protein coding gene Chr1:91151029-91489249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016650
 protein coding gene Chr1:81349954-81628900 (+)
PWK/PhJ MGP_PWKPhJ_G0015351
 protein coding gene Chr1:77756281-78034557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015129
 protein coding gene Chr1:80603746-80883723 (+)
WSB/EiJ MGP_WSBEiJ_G0015626
 protein coding gene Chr1:81109617-81403918 (+)



Homology
more
  • Human Ortholog
    NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
  • Synonyms
    KIAA1486
  • Links
    NCBI Gene ID: 57624
    neXtProt AC: NX_Q9P242
    UniProt: Q9P242

  • Chr Location
    2q36.3; chr2:225397939-225729887 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    8 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Nyap2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    35 strains or lines available
Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    16
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054976 Ensembl Gene Model | MGI Sequence Detail 264813 C57BL/6J ±  kb
transcript ENSMUST00000068275 Ensembl | MGI Sequence Detail 4919 Not Applicable  
polypeptide ENSMUSP00000065468 Ensembl | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000031028 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
    (term hierarchy)
  • InterPro Domains
    IPR026722 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2
    IPR029353 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain
    IPR039482 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, N-terminal
  • GlyGen
    Q8BM65 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:322321 Catela C, et al., Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Elife. 2022 Mar 22;11:e70766
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory