Lims2 MGI Mouse Gene Detail - MGI:2385067 - LIM and senescent cell antigen like domains 2

Symbol

Lims2
Name

LIM and senescent cell antigen like domains 2
Synonyms

PINCH2

Feature Type

protein coding gene
IDs

MGI:2385067
NCBI Gene: 225341
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr18:32055346-32091673 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 17.89 cM
Mapping Data

1 experiment

SNPs within 2kb

2325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385067	protein coding gene	Chr18:32055343-32091673 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024220	protein coding gene	Chr18:30062395-30089343 (+)
A/J	MGP_AJ_G0024186	protein coding gene	Chr18:29059198-29086335 (+)
AKR/J	MGP_AKRJ_G0024155	protein coding gene	Chr18:29861691-29888810 (+)
BALB/cJ	MGP_BALBcJ_G0024186	protein coding gene	Chr18:29152143-29179269 (+)
C3H/HeJ	MGP_C3HHeJ_G0023954	protein coding gene	Chr18:29900485-29927614 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024628	protein coding gene	Chr18:31125548-31155505 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022069	protein coding gene	Chr18:29286305-29314136 (+)
CAST/EiJ	MGP_CASTEiJ_G0023429	protein coding gene	Chr18:29794834-29824988 (+)
CBA/J	MGP_CBAJ_G0023922	protein coding gene	Chr18:32088137-32117626 (+)
DBA/2J	MGP_DBA2J_G0024054	protein coding gene	Chr18:28732747-28760126 (+)
FVB/NJ	MGP_FVBNJ_G0024020	protein coding gene	Chr18:28436343-28463469 (+)
LP/J	MGP_LPJ_G0024135	protein coding gene	Chr18:30139515-30169185 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024048	protein coding gene	Chr18:33434334-33464365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024676	protein coding gene	Chr18:29729007-29757384 (+)
PWK/PhJ	MGP_PWKPhJ_G0023172	protein coding gene	Chr18:28891185-28918820 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022981	protein coding gene	Chr18:29956141-29986650 (+)
WSB/EiJ	MGP_WSBEiJ_G0023492	protein coding gene	Chr18:29630582-29657692 (+)

Human Ortholog

LIMS2, LIM zinc finger domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIMS2, LIM zinc finger domain containing 2
Synonyms

LGMD2W, MDRCMTT, PINCH-2, PINCH2
Links

HGNC:16084

NCBI Gene ID: 55679

UniProt: Q7Z4I7
Chr Location

2q14.3; chr2:127638381-127681786 (-) GRCh38

MGI Vertebrate Homology

Lims2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LIMS2
Protein SuperFamily

PINCH
Gene Tree

Lims2

Diseases

1 with human LIMS2 associations

				Human Disease	Mouse Models
				autosomal recessive limb-girdle muscular dystrophy type 2W IDs autosomal recessive limb-girdle muscular dystrophy type 2W DOID:0110288 OMIM:616827 ORDO:466801

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
23 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile with no gross abnormalities. Mice homozygous for a different targeted allele exhibit decreased fractional shortening and increased area affected following myocardial infarct.

less

All GO Annotations

19
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

78
cDNA Data

54
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN lims2

less

All Sequences

65
RefSeq

12
UniProt

6
CCDS

CCDS29113.1

Ensembl

ENSMUSG00000024395 (Evidence)
NCBI Gene

225341

			Length	Strain/Species	Flank
genomic	225341	NCBI Gene Model \| MGI Sequence Detail	36328	C57BL/6J	± kb
transcript	NM_001379138	RefSeq \| MGI Sequence Detail	1894	C57BL/6
polypeptide	Q91XD2	UniProt \| EBI \| MGI Sequence Detail	341	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000009819 LIM and senescent cell antigen-like-containing domain protein 2

(term hierarchy)
InterPro Domains

IPR047946 LIM and senescent cell antigen-like-containing domain protein 1/2-like

IPR017351 LIM and senescent cell antigen-like-containing domain protein 1-4-like

IPR047944 LIMS1/2-like, LIM domain 1

IPR001781 Zinc finger, LIM-type

less

All nucleic 55

cDNA 54

Primer pair 1

Microarray probesets 3

Summaries

All 44

Developmental Gene Expression 11

Gene Ontology 6

Phenotypes 13
Earliest

J:82868 Braun A, et al., PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res. 2003 Apr 1;284(2):239-50
Latest

J:361268 He T, et al., The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway. Cell Death Differ. 2024 Jan;31(1):90-105

TSS for Lims2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150372	Chr18:32055322-32055325 (+)	-22 bp
Tssr150373	Chr18:32055339-32055357 (+)	2 bp
Tssr150374	Chr18:32064328-32064336 (+)	8,986 bp
Tssr150375	Chr18:32064358-32064401 (+)	9,034 bp
Tssr150376	Chr18:32064506-32064513 (+)	9,164 bp
Tssr150377	Chr18:32064523-32064573 (+)	9,202 bp
Tssr150378	Chr18:32070323-32070341 (+)	14,986 bp
Tssr150379	Chr18:32087883-32087925 (+)	32,558 bp
Tssr150380	Chr18:32088160-32088182 (+)	32,825 bp
Tssr150381	Chr18:32091067-32091092 (+)	35,734 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24