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Kcnk13 Gene Detail
Summary
  • Symbol
    Kcnk13
  • Name
    potassium channel, subfamily K, member 13
  • Synonyms
    F730021E22Rik, LOC380778, LOC381712, THIK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384976
    NCBI Gene: 217826
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:99930758-100028941 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 50.43 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2994 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384976
 protein coding gene Chr12:99928132-100028941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020014
 protein coding gene Chr12:101417616-101516211 (+)
A/J MGP_AJ_G0019969
 protein coding gene Chr12:97611042-97708926 (+)
AKR/J MGP_AKRJ_G0019945
 protein coding gene Chr12:100242906-100342491 (+)
BALB/cJ MGP_BALBcJ_G0019955
 protein coding gene Chr12:97950171-98050454 (+)
C3H/HeJ MGP_C3HHeJ_G0019757
 protein coding gene Chr12:100783766-100885261 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020404
 protein coding gene Chr12:104536748-104640989 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018018
 protein coding gene Chr12:94576303-94681037 (+)
CAST/EiJ MGP_CASTEiJ_G0019303
 protein coding gene Chr12:95891543-95994640 (+)
CBA/J MGP_CBAJ_G0019729
 protein coding gene Chr12:108421859-108522340 (+)
DBA/2J MGP_DBA2J_G0019840
 protein coding gene Chr12:97042591-97140736 (+)
FVB/NJ MGP_FVBNJ_G0019829
 protein coding gene Chr12:95756599-95858914 (+)
LP/J MGP_LPJ_G0019916
 protein coding gene Chr12:101245997-101350445 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019871
 protein coding gene Chr12:112030724-112133504 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020433
 protein coding gene Chr12:99808764-99910422 (+)
PWK/PhJ MGP_PWKPhJ_G0019067
 protein coding gene Chr12:91669892-91788742 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018863
 protein coding gene Chr12:93987262-94096828 (+)
WSB/EiJ MGP_WSBEiJ_G0019357
 protein coding gene Chr12:100665224-100765739 (+)



Homology
more
  • Human Ortholog
    KCNK13, potassium two pore domain channel subfamily K member 13
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK13, potassium two pore domain channel subfamily K member 13
  • Synonyms
    K2p13.1, THIK-1, THIK1
  • Links
    NCBI Gene ID: 56659
    neXtProt AC: NX_Q9HB14
    UniProt: Q9HB14

  • Chr Location
    14q32.11; chr14:90061994-90185853 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Targeted
    2
  • Genomic Mutations
    1 involving Kcnk13
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    24 strains or lines available
Homozygous knockout reduces the surveillance activity of microglial cells in the brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045404 Ensembl Gene Model | MGI Sequence Detail 98184 C57BL/6J ±  kb
transcript ENSMUST00000160413 Ensembl | MGI Sequence Detail 3061 Not Applicable  
polypeptide ENSMUSP00000123916 Ensembl | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145065, MGI:2686416, MGI:2686531
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 14
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:345713 Rifat A, et al., Differential contribution of THIK-1 K(+) channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia. J Neuroinflammation. 2024 Feb 26;21(1):58
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory