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Metrnl Gene Detail
Summary
  • Symbol
    Metrnl
  • Name
    meteorin, glial cell differentiation regulator-like
  • Synonyms
    9430048M07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384806
    NCBI Gene: 210029
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:121592370-121607132 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 86.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384806
 protein coding gene Chr11:121592370-121608215 (+)
129S1/SvImJ ENSMUSG00200050664
 protein coding gene Chr11:118954999-118969774 (+)
A/J ENSMUSG00195028811
 protein coding gene Chr11:118632300-118647067 (+)
AKR/J ENSMUSG00220023461
 protein coding gene Chr11:118782640-118797407 (+)
BALB/cJ ENSMUSG00180046759
 protein coding gene Chr11:118929120-118943886 (+)
C3H/HeJ ENSMUSG00175031785
 protein coding gene Chr11:118882667-118897433 (+)
C57BL/6NJ ENSMUSG00215041414
 protein coding gene Chr11:118452756-118467518 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017569
 protein coding gene Chr11:117600386-117614161 (+)
CAST/EiJ ENSTCUG00005033961
 protein coding gene Chr11:118289867-118304738 (+)
CBA/J ENSMUSG00210048965
 protein coding gene Chr11:118596708-118611474 (+)
DBA/2J ENSMUSG00185023903
 protein coding gene Chr11:118909858-118924623 (+)
FVB/NJ ENSMUSG00205034841
 protein coding gene Chr11:118755512-118770276 (+)
JF1/MsJ ENSUMUG00000051122
 protein coding gene Chr11:119196400-119210851 (+)
LP/J ENSMUSG00230048282
 protein coding gene Chr11:119971366-119986132 (+)
NOD/ShiLtJ ENSMUSG00190028499
 protein coding gene Chr11:118981088-118995852 (+)
NZO/HlLtJ ENSMUSG00225026731
 protein coding gene Chr11:122141349-122156114 (+)
PWK/PhJ ENSLUMG00010019410
 protein coding gene Chr11:118697376-118711809 (+)
SPRET/EiJ ENSMSPG00010033674
 protein coding gene Chr11:119333920-119348896 (+)
WSB/EiJ ENSIUOG00005038411
 protein coding gene Chr11:118718188-118733055 (+)



Homology
more
  • Human Ortholog
    METRNL, meteorin like, glial cell differentiation regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METRNL, meteorin like, glial cell differentiation regulator
  • Links
    NCBI Gene ID: 284207
    UniProt: Q641Q3

  • Chr Location
    17q25.3; chr17:83079609-83095122 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased LPS-induced mortality, altered Ig serum levels and inflammation in the uterus, kidney and liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    50
  • cDNA Data
    47
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039208 Ensembl Gene Model | MGI Sequence Detail 14763 C57BL/6J ±  kb
    transcript ENSMUST00000036742 Ensembl | MGI Sequence Detail 1401 Not Applicable  
    polypeptide ENSMUSP00000038126 Ensembl | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2444092
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:389185 Blasco-Roset A, et al., Meteorin-like controls metabolic adaptations and physiological myocardial remodeling in pregnancy and lactation. Front Endocrinol (Lausanne). 2026;17:1823116
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory