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Sectm1a Gene Detail
Summary
  • Symbol
    Sectm1a
  • Name
    secreted and transmembrane 1A
  • Synonyms
    MGC:7970
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384805
    NCBI Gene: 209588
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120958233-120972046 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    563 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384805
 protein coding gene Chr11:120958221-120988023 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019537
 protein coding gene Chr11:125598031-125608911 (-)
A/J MGP_AJ_G0019504
 protein coding gene Chr11:119990318-120000071 (-)
AKR/J MGP_AKRJ_G0019474
 protein coding gene Chr11:123617280-123626238 (-)
BALB/cJ MGP_BALBcJ_G0019479
 protein coding gene Chr11:120360051-120368909 (-)
C3H/HeJ MGP_C3HHeJ_G0019285
 protein coding gene Chr11:123945353-123954783 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019928
 protein coding gene Chr11:129399399-129414865 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017553
 protein coding gene Chr11:116970374-116981002 (-)
CAST/EiJ MGP_CASTEiJ_G0018839
 protein coding gene Chr11:125446790-125460807 (-)
CBA/J MGP_CBAJ_G0019256
 protein coding gene Chr11:134433317-134444346 (-)
DBA/2J MGP_DBA2J_G0019369
 protein coding gene Chr11:119359098-119368508 (-)
FVB/NJ MGP_FVBNJ_G0019360
 protein coding gene Chr11:119076422-119085230 (-)
LP/J MGP_LPJ_G0019440
 protein coding gene Chr11:125877603-125886412 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019393
 protein coding gene Chr11:133249921-133259888 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019967
 protein coding gene Chr11:124298696-124307554 (-)
PWK/PhJ MGP_PWKPhJ_G0018605
 protein coding gene Chr11:120799203-120808253 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018397
 protein coding gene Chr11:124054101-124063037 (-)
WSB/EiJ MGP_WSBEiJ_G0018892
 protein coding gene Chr11:124273823-124282658 (-)



Homology
more
  • Human Ortholog
    SECTM1, secreted and transmembrane 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SECTM1, secreted and transmembrane 1
  • Synonyms
    K12, SECTM
  • Links
    NCBI Gene ID: 6398
    UniProt: Q8WVN6

  • Chr Location
    17q25.3; chr17:82321024-82334074 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased mortality and cardiac injury after LPS injection, with increased inflammatory macrophages in hearts and inflammatory cytokine levels in macrophages, serum and hearts. High-fat feeding results in increased heart inflammation and worsened cardiac function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025165 Ensembl Gene Model | MGI Sequence Detail 13814 C57BL/6J ±  kb
    transcript ENSMUST00000026162 Ensembl | MGI Sequence Detail 1692 Not Applicable  
    polypeptide ENSMUSP00000026162 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:352340 Wang X, et al., Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI Insight. 2024 Mar 8;9(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory