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Arfgap1 Gene Detail
Summary
  • Symbol
    Arfgap1
  • Name
    ARF GTPase activating protein 1
  • Synonyms
    ARF1 GAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183559
    NCBI Gene: 228998
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180609018-180624319 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    392 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183559
 protein coding gene Chr2:180608290-180624319 (+)
129S1/SvImJ ENSMUSG00200001681
 protein coding gene Chr2:176631533-176646825 (+)
A/J ENSMUSG00195001078
 protein coding gene Chr2:176868703-176884005 (+)
AKR/J ENSMUSG00220000059
 protein coding gene Chr2:174547340-174562643 (+)
BALB/cJ ENSMUSG00180000433
 protein coding gene Chr2:174670766-174686058 (+)
C3H/HeJ ENSMUSG00175004208
 protein coding gene Chr2:175829289-175844591 (+)
C57BL/6NJ ENSMUSG00215002476
 protein coding gene Chr2:174770957-174786257 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024793
 protein coding gene Chr2:170506490-170521755 (+)
CAST/EiJ ENSTCUG00005000738
 protein coding gene Chr2:174123893-174139193 (+)
CBA/J ENSMUSG00210001324
 protein coding gene Chr2:175149343-175164635 (+)
DBA/2J ENSMUSG00185019537
 protein coding gene Chr2:176388734-176404036 (+)
FVB/NJ ENSMUSG00205002190
 protein coding gene Chr2:175201062-175216363 (+)
JF1/MsJ ENSUMUG00000019881
 protein coding gene Chr2:177574032-177589306 (+)
LP/J ENSMUSG00230021204
 protein coding gene Chr2:178282474-178297764 (+)
NOD/ShiLtJ ENSMUSG00190015544
 protein coding gene Chr2:174690928-174706219 (+)
NZO/HlLtJ ENSMUSG00225006288
 protein coding gene Chr2:186369246-186384547 (+)
PWK/PhJ ENSLUMG00010000342
 protein coding gene Chr2:175000123-175015386 (+)
SPRET/EiJ ENSMSPG00010003881
 protein coding gene Chr2:177473670-177488964 (+)
WSB/EiJ ENSIUOG00005000163
 protein coding gene Chr2:174714713-174730014 (+)



Homology
more
  • Human Ortholog
    ARFGAP1, ARF GTPase activating protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARFGAP1, ARF GTPase activating protein 1
  • Synonyms
    ARF1GAP, HRIHFB2281
  • Links
    NCBI Gene ID: 55738
    UniProt: Q8N6T3

  • Chr Location
    20q13.33; chr20:63272785-63289790 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    14
  • Endonuclease-mediated
    2
  • Gene trapped
    8
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Arfgap1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    27 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    15
  • cDNA Data
    17
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027575 Ensembl Gene Model | MGI Sequence Detail 15302 C57BL/6J ±  kb
transcript ENSMUST00000185115 Ensembl | MGI Sequence Detail 1393 Not Applicable  
polypeptide ENSMUSP00000139222 Ensembl | MGI Sequence Detail 424 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000004206 ADP-ribosylation factor GTPase-activating protein 1
    (term hierarchy)
  • InterPro Domains
    IPR038508 ArfGAP domain superfamily
    IPR037278 ARFGAP/RecO-like, zinc finger superfamily
    IPR001164 Arf GTPase activating protein
  • GlyGen
    Q9EPJ9 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138836
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:82964 Yang Y, et al., Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Hum Mol Genet. 2003 May 1;12(9):975-84
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory