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Srek1 Gene Detail
Summary
  • Symbol
    Srek1
  • Name
    splicing regulatory glutamine/lysine-rich protein 1
  • Synonyms
    AL118220, Sfrs12, SRrp508, SRrp86
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145245
    NCBI Gene: 218543
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:103875856-103911116 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1808 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145245
 protein coding gene Chr13:103873291-103911379 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020900
 protein coding gene Chr13:105825613-105849676 (-)
A/J MGP_AJ_G0020851
 protein coding gene Chr13:101701279-101724114 (-)
AKR/J MGP_AKRJ_G0020826
 protein coding gene Chr13:104792214-104815036 (-)
BALB/cJ MGP_BALBcJ_G0020851
 protein coding gene Chr13:102404041-102436147 (-)
C3H/HeJ MGP_C3HHeJ_G0020640
 protein coding gene Chr13:104538277-104561862 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021285
 protein coding gene Chr13:109003302-109028754 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018855
 protein coding gene Chr13:97323671-97345575 (-)
CAST/EiJ MGP_CASTEiJ_G0020159
 protein coding gene Chr13:103992523-104018248 (-)
CBA/J MGP_CBAJ_G0020602
 protein coding gene Chr13:113267817-113293571 (-)
DBA/2J MGP_DBA2J_G0020726
 protein coding gene Chr13:101471252-101496464 (-)
FVB/NJ MGP_FVBNJ_G0020708
 protein coding gene Chr13:100159253-100182106 (-)
LP/J MGP_LPJ_G0020800
 protein coding gene Chr13:105845463-105868422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020736
 protein coding gene Chr13:113415493-113438158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021324
 protein coding gene Chr13:104277527-104302111 (-)
PWK/PhJ MGP_PWKPhJ_G0019912
 protein coding gene Chr13:100206104-100228550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019734
 protein coding gene Chr13:100468008-100493015 (-)
WSB/EiJ MGP_WSBEiJ_G0020217
 protein coding gene Chr13:104737276-104761009 (-)



Homology
more
  • Human Ortholog
    SREK1, splicing regulatory glutamic acid and lysine rich protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SREK1, splicing regulatory glutamic acid and lysine rich protein 1
  • Synonyms
    SFRS12, SRrp508, SRrp86
  • Links
    NCBI Gene ID: 140890
    UniProt: Q8WXA9

  • Chr Location
    5q12.3; chr5:66139971-66183615 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032621 Ensembl Gene Model | MGI Sequence Detail 35261 C57BL/6J ±  kb
    transcript ENSMUST00000074616 Ensembl | MGI Sequence Detail 3934 Not Applicable  
    polypeptide ENSMUSP00000074196 Ensembl | MGI Sequence Detail 610 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014751 splicing factor, arginine/serine-rich 12
      (term hierarchy)
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR034192 SREK1, RNA recognition motif 2
    • GlyGen
      Q8BZX4 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145251, MGI:3034554
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory