Slc9b2 MGI Mouse Gene Detail - MGI:2140077 - solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2

Symbol

Slc9b2
Name

solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms

C80638, NHA2, nha-oc, NHE10, Nhedc2

Feature Type

protein coding gene
IDs

MGI:2140077
NCBI Gene: 97086
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:135013083-135048606 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 62.55 cM
Mapping Data

1 experiment

SNPs within 2kb

1506 from dbSNP Build 142
Strain Annotations

22

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140077	protein coding gene	Chr3:135013083-135051148 (+)
129S1/SvImJ	ENSMUSG00200002255	protein coding gene	Chr3:131793865-131795181 (+)
A/J	ENSMUSG00195004045	protein coding gene	Chr3:131920524-131921835 (+)
A/J	ENSMUSGG00195055175	protein coding gene	Chr3:131925356-131929739 (+)
AKR/J	ENSMUSG00220022132	protein coding gene	Chr3:130372490-130373799 (+)
BALB/cJ	ENSMUSG00180011613	protein coding gene	Chr3:131842297-131843608 (+)
BALB/cJ	ENSMUSGG00180055490	protein coding gene	Chr3:131847129-131851512 (+)
C3H/HeJ	ENSMUSGG00175054971	protein coding gene	Chr3:131448076-131452459 (+)
C3H/HeJ	ENSMUSG00175018304	protein coding gene	Chr3:131443244-131444555 (+)
C57BL/6NJ	ENSMUSGG00215055725	protein coding gene	Chr3:132185375-132189758 (+)
C57BL/6NJ	ENSMUSG00215016105	protein coding gene	Chr3:132180543-132181854 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025656	protein coding gene	Chr3:128573360-128608535 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210031723	protein coding gene	Chr3:132033129-132034440 (+)
CBA/J	ENSMUSGG00210054856	protein coding gene	Chr3:132037961-132042344 (+)
DBA/2J	ENSMUSGG00185057882	protein coding gene	Chr3:132675745-132680128 (+)
DBA/2J	ENSMUSG00185003280	protein coding gene	Chr3:132670913-132672224 (+)
FVB/NJ	ENSMUSGG00205054552	protein coding gene	Chr3:130989736-130994119 (+)
FVB/NJ	ENSMUSG00205020932	protein coding gene	Chr3:130984904-130986215 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230002465	protein coding gene	Chr3:134607903-134609219 (+)
NOD/ShiLtJ	ENSMUSGG00190054986	protein coding gene	Chr3:133054686-133059069 (+)
NOD/ShiLtJ	ENSMUSG00190004383	protein coding gene	Chr3:133049854-133051165 (+)
NZO/HlLtJ	ENSMUSG00225005025	protein coding gene	Chr3:137089371-137090680 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

SLC9B2, solute carrier family 9 member B2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC9B2, solute carrier family 9 member B2
Synonyms

NHA2, NHE10, NHEDC2
Links

HGNC:25143

NCBI Gene ID: 133308

UniProt: Q86UD5
Chr Location

4q24; chr4:103018029-103085829 (-) GRCh38

MGI Vertebrate Homology

Slc9b2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: SLC9B2
Gene Tree

Slc9b2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 3 alleles in 4 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

34
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving Slc9b2
Incidental Mutations

APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele are viable and overtly normal, with no detectable abnormalities in osteoclast differentiation and function.

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All GO Annotations

49
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

668
Tissues

15
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc9b2

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All Sequences

68
RefSeq

24
UniProt

3
CCDS

CCDS17854.1

Ensembl

ENSMUSG00000037994 (Evidence)
NCBI Gene

97086

			Length	Strain/Species	Flank
genomic	97086	NCBI Gene Model \| MGI Sequence Detail	35524	C57BL/6J	± kb
transcript	NM_178877	RefSeq \| MGI Sequence Detail	2028	C57BL/6
polypeptide	Q5BKR2	UniProt \| EBI \| MGI Sequence Detail	547	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011198 sodium/hydrogen exchanger 9B2

(term hierarchy)
InterPro Domains

IPR006153 Cation/H+ exchanger, transmembrane domain

IPR051843 Monovalent cation:proton antiporter 1

IPR038770 Sodium/solute symporter superfamily

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All nucleic 9

cDNA 9

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 2

Diseases 1

Gene Ontology 16

Phenotypes 22
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc9b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31804	Chr3:135013442-135013467 (+)	372 bp
Tssr31805	Chr3:135013472-135013511 (+)	409 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24