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Sytl3 Gene Detail
Summary
  • Symbol
    Sytl3
  • Name
    synaptotagmin-like 3
  • Synonyms
    Slp3, Slp3-a, Slp3-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933367
    NCBI Gene: 83672
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:6926492-7005443 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.33 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1411 from dbSNP Build 142
  • Strain Annotations
    25
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933367
 protein coding gene Chr17:6925633-7005449 (+)
129S1/SvImJ ENSMUSG00200034151
 protein coding gene Chr17:3439282-3472604 (+)
129S1/SvImJ ENSMUSGG00200054697
 protein coding gene Chr17:3405973-3436637 (+)
A/J ENSMUSGG00195054969
 protein coding gene Chr17:3370183-3400026 (+)
A/J ENSMUSG00195022300
 protein coding gene Chr17:3402676-3435716 (+)
AKR/J ENSMUSG00220024787
 protein coding gene Chr17:3568243-3601282 (+)
AKR/J ENSMUSGG00220054316
 protein coding gene Chr17:3535764-3565597 (+)
BALB/cJ ENSMUSG00180022882
 protein coding gene Chr17:3211934-3264722 (+)
C3H/HeJ ENSMUSG00175032454
 protein coding gene Chr17:3162983-3226369 (+)
C57BL/6NJ ENSMUSGG00215055408
 protein coding gene Chr17:3439965-3469343 (+)
C57BL/6NJ ENSMUSG00215017817
 protein coding gene Chr17:3472214-3504889 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021033
 protein coding gene Chr17:3203287-3267955 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054471
 protein coding gene Chr17:3213028-3242935 (+)
CBA/J ENSMUSG00210033398
 protein coding gene Chr17:3245584-3278635 (+)
DBA/2J ENSMUSGG00185057663
 protein coding gene Chr17:3920284-3950124 (+)
DBA/2J ENSMUSG00185022946
 protein coding gene Chr17:3705761-3734611 (+)
DBA/2J ENSMUSG00185023065
 protein coding gene Chr17:3952810-3985943 (+)
FVB/NJ ENSMUSG00205007851
 protein coding gene Chr17:3365180-3395815 (-)
FVB/NJ ENSMUSGG00205054304
 protein coding gene Chr17:3486305-3515662 (+)
FVB/NJ ENSMUSG00205007884
 protein coding gene Chr17:3518539-3551190 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055603
 protein coding gene Chr17:5328158-5358001 (+)
LP/J ENSMUSG00230031191
 protein coding gene Chr17:5360687-5393820 (+)
NOD/ShiLtJ ENSMUSG00190034982
 protein coding gene Chr17:3301594-3332224 (-)
NZO/HlLtJ ENSMUSG00225028807
 protein coding gene Chr17:7311530-7344663 (+)
NZO/HlLtJ ENSMUSGG00225055210
 protein coding gene Chr17:7279002-7308844 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SYTL3, synaptotagmin like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYTL3, synaptotagmin like 3
  • Synonyms
    SLP3
  • Links
    NCBI Gene ID: 94120
    UniProt: Q4VX76

  • Chr Location
    6q25.3; chr6:158644387-158768355 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    378 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    666
  • Tissues
    14
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041831 Ensembl Gene Model | MGI Sequence Detail 78952 C57BL/6J ±  kb
    transcript ENSMUST00000097430 Ensembl | MGI Sequence Detail 2423 Not Applicable  
    polypeptide ENSMUSP00000095041 Ensembl | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 404
      Developmental Gene Expression 3
      Diseases 6
      Gene Ontology 8
      Phenotypes 378
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory