About   Help   FAQ
Rbm5 Gene Detail
Summary
  • Symbol
    Rbm5
  • Name
    RNA binding motif protein 5
  • Synonyms
    D030069N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933204
    NCBI Gene: 83486
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107617694-107648228 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    686 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933204
 protein coding gene Chr9:107617570-107648228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035269
 protein coding gene Chr9:109640705-109674001 (-)
A/J MGP_AJ_G0035248
 protein coding gene Chr9:105641544-105671770 (-)
AKR/J MGP_AKRJ_G0035180
 protein coding gene Chr9:108277991-108309585 (-)
BALB/cJ MGP_BALBcJ_G0035242
 protein coding gene Chr9:105310453-105340891 (-)
C3H/HeJ MGP_C3HHeJ_G0034952
 protein coding gene Chr9:108674412-108704690 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035762
 protein coding gene Chr9:112620421-112651036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032660
 protein coding gene Chr9:103069269-103099537 (-)
CAST/EiJ MGP_CASTEiJ_G0034263
 protein coding gene Chr9:108621486-108659151 (-)
CBA/J MGP_CBAJ_G0034920
 protein coding gene Chr9:116589508-116623715 (-)
DBA/2J MGP_DBA2J_G0035081
 protein coding gene Chr9:105095255-105129994 (-)
FVB/NJ MGP_FVBNJ_G0035029
 protein coding gene Chr9:103862992-103893026 (-)
LP/J MGP_LPJ_G0035157
 protein coding gene Chr9:109834641-109866185 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035068
 protein coding gene Chr9:118205523-118237431 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035783
 protein coding gene Chr9:108553869-108585479 (-)
PWK/PhJ MGP_PWKPhJ_G0033970
 protein coding gene Chr9:105416190-105447740 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033805
 protein coding gene Chr9:108603874-108635039 (-)
WSB/EiJ MGP_WSBEiJ_G0034384
 protein coding gene Chr9:108429407-108463116 (-)



Homology
more
  • Human Ortholog
    RBM5, RNA binding motif protein 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBM5, RNA binding motif protein 5
  • Synonyms
    G15, H37, LUCA-15, LUCA15, RMB5
  • Links
    NCBI Gene ID: 10181
    neXtProt AC: NX_P52756
    UniProt: P52756

  • Chr Location
    3p21.31; chr3:50088919-50119021 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit male infertility with azoospermia, male germ cell apoptosis, round spermatid arrest and spermatid differentiation arrest.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    27
  • cDNA Data
    268
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83486 NCBI Gene Model | MGI Sequence Detail 30535 C57BL/6J ±  kb
    transcript NR_153190 RefSeq | MGI Sequence Detail 3435 C57BL/6  
    polypeptide Q91YE7 UniProt | EBI | MGI Sequence Detail 815 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 271
      cDNA 268
      Primer pair 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2443530
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:66052 Lerman MI, et al., The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium [In Process Citation]. Cancer Res. 2000 Nov 1;60(21):6116-33
    • Latest
      J:340693 Mullari M, et al., Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease. Nat Commun. 2023 Jul 19;14(1):4348
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory