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Misp Gene Detail
Summary
  • Symbol
    Misp
  • Name
    mitotic spindle positioning
  • Synonyms
    9130017N09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926156
    NCBI Gene: 78906
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79656853-79666286 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926156
 protein coding gene Chr10:79656823-79666324 (+)
129S1/SvImJ ENSMUSG00200049201
 protein coding gene Chr10:76280502-76290003 (+)
A/J ENSMUSG00195038202
 protein coding gene Chr10:76676040-76685544 (+)
AKR/J ENSMUSG00220042842
 protein coding gene Chr10:76273594-76283096 (+)
BALB/cJ ENSMUSG00180044413
 protein coding gene Chr10:76686515-76696021 (+)
C3H/HeJ ENSMUSG00175051903
 protein coding gene Chr10:76557201-76566701 (+)
C57BL/6NJ ENSMUSG00215049465
 protein coding gene Chr10:76298892-76308395 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015544
 protein coding gene Chr10:73805827-73811429 (+)
CAST/EiJ ENSTCUG00005048759
 protein coding gene Chr10:76183476-76193000 (+)
CBA/J ENSMUSG00210044583
 protein coding gene Chr10:76413284-76422786 (+)
DBA/2J ENSMUSG00185045803
 protein coding gene Chr10:76755665-76765173 (+)
FVB/NJ ENSMUSG00205045788
 protein coding gene Chr10:76468456-76477960 (+)
JF1/MsJ ENSUMUG00000041300
 protein coding gene Chr10:77986224-77995693 (+)
LP/J ENSMUSG00230051025
 protein coding gene Chr10:78525433-78534934 (+)
NOD/ShiLtJ ENSMUSG00190046495
 protein coding gene Chr10:76669487-76678986 (+)
NZO/HlLtJ ENSMUSG00225049773
 protein coding gene Chr10:82811770-82821273 (+)
PWK/PhJ ENSLUMG00010037028
 protein coding gene Chr10:76345675-76355163 (+)
SPRET/EiJ ENSMSPG00010036718
 protein coding gene Chr10:77965253-77975023 (+)
WSB/EiJ ENSIUOG00005049579
 protein coding gene Chr10:76373543-76383041 (+)



Homology
more
  • Human Ortholog
    MISP, mitotic spindle positioning
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MISP, mitotic spindle positioning
  • Synonyms
    C19orf21, MISP1
  • Links
    NCBI Gene ID: 126353
    UniProt: Q8IVT2

  • Chr Location
    19p13.3; chr19:748404-764363 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit exacerbated dextran sulfate sodium (DSS)-induced colitis with significant increases in weight loss, more severe symptoms (bloody stools and diarrhea), and extensive crypt loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    7
  • cDNA Data
    42
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78906 NCBI Gene Model | MGI Sequence Detail 9434 C57BL/6J ±  kb
    transcript NM_030218 RefSeq | MGI Sequence Detail 2427 C57BL/6  
    polypeptide Q9D279 UniProt | EBI | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:363871 Hiura K, et al., Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway. Int J Mol Sci. 2024 Mar 6;25(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory