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Nuak2 Gene Detail
Summary
  • Symbol
    Nuak2
  • Name
    NUAK family, SNF1-like kinase, 2
  • Synonyms
    1200013B22Rik, mKIAA0537, Snark
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921387
    NCBI Gene: 74137
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132243864-132261226 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.24 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921387
 protein coding gene Chr1:132243827-132261233 (+)
129S1/SvImJ ENSMUSG00200007844
 protein coding gene Chr1:129806898-129824435 (+)
A/J ENSMUSG00195041799
 protein coding gene Chr1:128908601-128925972 (+)
AKR/J ENSMUSG00220045220
 protein coding gene Chr1:128738108-128755645 (+)
BALB/cJ ENSMUSG00180037976
 protein coding gene Chr1:129454787-129472158 (+)
C3H/HeJ ENSMUSG00175036854
 protein coding gene Chr1:129153137-129170504 (+)
C57BL/6NJ ENSMUSG00215042281
 protein coding gene Chr1:129168932-129186298 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014585
 protein coding gene Chr1:123903626-123920755 (+)
CAST/EiJ ENSTCUG00005032035
 protein coding gene Chr1:128069862-128087015 (+)
CBA/J ENSMUSG00210025703
 protein coding gene Chr1:129049557-129066928 (+)
DBA/2J ENSMUSG00185029869
 protein coding gene Chr1:133405704-133423231 (+)
FVB/NJ ENSMUSG00205034482
 protein coding gene Chr1:128385951-128403322 (+)
JF1/MsJ ENSUMUG00000047478
 protein coding gene Chr1:132567110-132584242 (+)
LP/J ENSMUSG00230035415
 protein coding gene Chr1:132993985-133011348 (+)
NOD/ShiLtJ ENSMUSG00190041650
 protein coding gene Chr1:129063133-129080498 (+)
NZO/HlLtJ ENSMUSG00225017625
 protein coding gene Chr1:136714132-136731640 (+)
PWK/PhJ ENSLUMG00010025889
 protein coding gene Chr1:128185302-128202488 (+)
SPRET/EiJ ENSMSPG00010044751
 protein coding gene Chr1:130985305-131002693 (+)
WSB/EiJ ENSIUOG00005042535
 protein coding gene Chr1:128795502-128812821 (+)



Homology
more
  • Human Ortholog
    NUAK2, NUAK family kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUAK2, NUAK family kinase 2
  • Synonyms
    ANPH2, SNARK
  • Links
    NCBI Gene ID: 81788
    UniProt: Q9H093

  • Chr Location
    1q32.1; chr1:205302063-205321745 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NUAK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous null mice are exencephalic and die at E16.5 while survivors show a higher number of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in colon. Heterozygotes show increased susceptibility to AOM-induced ACF formation and colon tumors, mature-onset obesity and metabolic disorders.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    28
  • cDNA Data
    50
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009772 Ensembl Gene Model | MGI Sequence Detail 17363 C57BL/6J ±  kb
    transcript ENSMUST00000072177 Ensembl | MGI Sequence Detail 2936 Not Applicable  
    polypeptide ENSMUSP00000072039 Ensembl | MGI Sequence Detail 639 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 50
      Primer pair 2
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:372241 Jo H, et al., A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma. EMBO Mol Med. 2025 Sep;17(9):2409-2437
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory