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Thoc1 Gene Detail
Summary
  • Symbol
    Thoc1
  • Name
    THO complex 1
  • Synonyms
    3110002N20Rik, MGC:28284, NMP-84
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919668
    NCBI Gene: 225160
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:9958176-9995486 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    872 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919668
 protein coding gene Chr18:9957906-9995489 (+)
129S1/SvImJ ENSMUSG00200024300
 protein coding gene Chr18:6903141-6941750 (+)
A/J ENSMUSG00195008423
 protein coding gene Chr18:7067652-7105219 (+)
AKR/J ENSMUSG00220018472
 protein coding gene Chr18:7058824-7096388 (+)
BALB/cJ ENSMUSG00180005298
 protein coding gene Chr18:7514788-7552394 (+)
C3H/HeJ ENSMUSG00175007297
 protein coding gene Chr18:7050150-7087761 (+)
C57BL/6NJ ENSMUSG00215010592
 protein coding gene Chr18:6794444-6832031 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021989
 protein coding gene Chr18:6380304-6417669 (+)
CAST/EiJ ENSTCUG00005016064
 protein coding gene Chr18:6901153-6939455 (+)
CBA/J ENSMUSG00210021369
 protein coding gene Chr18:7063042-7100654 (+)
DBA/2J ENSMUSG00185028425
 protein coding gene Chr18:7072756-7110351 (+)
FVB/NJ ENSMUSG00205024160
 protein coding gene Chr18:6851949-6889552 (+)
JF1/MsJ ENSUMUG00000029250
 protein coding gene Chr18:7146665-7185217 (+)
LP/J ENSMUSG00230026735
 protein coding gene Chr18:9147767-9188672 (+)
NOD/ShiLtJ ENSMUSG00190009327
 protein coding gene Chr18:6845557-6883136 (+)
NZO/HlLtJ ENSMUSG00225033186
 protein coding gene Chr18:9056223-9093818 (+)
PWK/PhJ ENSLUMG00010008609
 protein coding gene Chr18:7335477-7374103 (+)
SPRET/EiJ ENSMSPG00010011515
 protein coding gene Chr18:6972877-7012733 (+)
WSB/EiJ ENSIUOG00005026121
 protein coding gene Chr18:6923911-6961546 (+)



Homology
more
  • Human Ortholog
    THOC1, THO complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THOC1, THO complex subunit 1
  • Synonyms
    DFNA86, HPR1, P84, P84N5
  • Links
    NCBI Gene ID: 9984
    UniProt: Q96FV9

  • Chr Location
    18p11.32; chr18:214515-268053 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human THOC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in embryonic lethality around implantation in homozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    14
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225160 NCBI Gene Model | MGI Sequence Detail 37311 C57BL/6J ±  kb
    transcript NM_001417754 RefSeq | MGI Sequence Detail 4036 C57BL/6  
    polypeptide Q8R3N6 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1
      Antibodies 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147345
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory