About   Help   FAQ
Megf6 Gene Detail
Summary
  • Symbol
    Megf6
  • Name
    multiple EGF-like-domains 6
  • Synonyms
    2600001P17Rik, Egfl3, MGC:49785
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919351
    NCBI Gene: 230971
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154255187-154360170 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3871 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919351
 protein coding gene Chr4:154255156-154360178 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029194
 protein coding gene Chr4:158424184-158537276 (+)
A/J MGP_AJ_G0029159
 protein coding gene Chr4:151774628-151880349 (+)
AKR/J MGP_AKRJ_G0029107
 protein coding gene Chr4:155918385-156028836 (+)
BALB/cJ MGP_BALBcJ_G0029175
 protein coding gene Chr4:152243902-152350953 (+)
C3H/HeJ MGP_C3HHeJ_G0028896
 protein coding gene Chr4:156454844-156564369 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029624
 protein coding gene Chr4:164089747-164204835 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026870
 protein coding gene Chr4:144077483-144184361 (+)
CAST/EiJ MGP_CASTEiJ_G0028309
 protein coding gene Chr4:153856209-153967329 (+)
CBA/J MGP_CBAJ_G0028858
 protein coding gene Chr4:169015337-169140137 (+)
DBA/2J MGP_DBA2J_G0029007
 protein coding gene Chr4:151801480-151909313 (+)
FVB/NJ MGP_FVBNJ_G0028971
 protein coding gene Chr4:151004058-151113831 (+)
LP/J MGP_LPJ_G0029097
 protein coding gene Chr4:158333421-158444759 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028998
 protein coding gene Chr4:171931879-172046554 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029656
 protein coding gene Chr4:156480349-156591663 (+)
PWK/PhJ MGP_PWKPhJ_G0028029
 protein coding gene Chr4:147885268-147998865 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027863
 protein coding gene Chr4:150779533-150892328 (+)
WSB/EiJ MGP_WSBEiJ_G0028389
 protein coding gene Chr4:156651105-156762452 (+)



Homology
more
  • Human Ortholog
    MEGF6, multiple EGF like domains 6
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEGF6, multiple EGF like domains 6
  • Synonyms
    EGFL3
  • Links
    NCBI Gene ID: 1953
    UniProt: O75095

  • Chr Location
    1p36.32; chr1:3487951-3624786 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    18
  • cDNA Data
    60
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057751 Ensembl Gene Model | MGI Sequence Detail 104984 C57BL/6J ±  kb
    transcript ENSMUST00000030897 Ensembl | MGI Sequence Detail 6851 Not Applicable  
    polypeptide ENSMUSP00000030897 Ensembl | MGI Sequence Detail 1572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 60
      Primer pair 1

      Microarray probesets 13
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:271659 Wang Y, et al., Generation and characterization of Megf6 null and Cre knock-in alleles. Genesis. 2019 Feb;57(2):e23262
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory