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Ints12 Gene Detail
Summary
  • Symbol
    Ints12
  • Name
    integrator complex subunit 12
  • Synonyms
    1110020M19Rik, 2810027J24Rik, 4930529N21Rik, A230056J18Rik, Phf22
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919043
    NCBI Gene: 71793
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:132797616-132816749 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.56 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    863 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919043
 protein coding gene Chr3:132797601-132816749 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027896
 protein coding gene Chr3:135876419-135896911 (+)
A/J MGP_AJ_G0027854
 protein coding gene Chr3:131088869-131108129 (+)
AKR/J MGP_AKRJ_G0027819
 protein coding gene Chr3:134512729-134531909 (+)
BALB/cJ MGP_BALBcJ_G0027867
 protein coding gene Chr3:130924617-130943727 (+)
C3H/HeJ MGP_C3HHeJ_G0027596
 protein coding gene Chr3:134892547-134915926 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028310
 protein coding gene Chr3:140632605-140651783 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025648
 protein coding gene Chr3:126517402-126536701 (+)
CAST/EiJ MGP_CASTEiJ_G0027052
 protein coding gene Chr3:134656792-134683132 (+)
CBA/J MGP_CBAJ_G0027572
 protein coding gene Chr3:145403327-145422550 (+)
DBA/2J MGP_DBA2J_G0027712
 protein coding gene Chr3:130250870-130269941 (+)
FVB/NJ MGP_FVBNJ_G0027679
 protein coding gene Chr3:127831560-127850736 (+)
LP/J MGP_LPJ_G0027822
 protein coding gene Chr3:137349195-137369510 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027710
 protein coding gene Chr3:153372755-153397414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028368
 protein coding gene Chr3:134167207-134186341 (+)
PWK/PhJ MGP_PWKPhJ_G0026776
 protein coding gene Chr3:130019299-130038507 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026601
 protein coding gene Chr3:132243265-132262433 (+)
WSB/EiJ MGP_WSBEiJ_G0027131
 protein coding gene Chr3:134937012-134956172 (+)



Homology
more
  • Human Ortholog
    INTS12, integrator complex subunit 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS12, integrator complex subunit 12
  • Synonyms
    INT12, PHF22, SBBI22
  • Links
    NCBI Gene ID: 57117
    UniProt: Q96CB8

  • Chr Location
    4q24; chr4:105682627-105895986 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    92
  • cDNA Data
    54
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71793 NCBI Gene Model | MGI Sequence Detail 19134 C57BL/6J ±  kb
    transcript NM_027927 RefSeq | MGI Sequence Detail 3099 C57BL/6  
    polypeptide Q9D168 UniProt | EBI | MGI Sequence Detail 461 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 54
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919937, MGI:1922431, MGI:2139786, MGI:2444032
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory