Gpr39 MGI Mouse Gene Detail - MGI:1918361 - G protein-coupled receptor 39

Symbol

Gpr39
Name

G protein-coupled receptor 39
Synonyms

4933415E13Rik

Feature Type

protein coding gene
IDs

MGI:1918361
NCBI Gene: 71111
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:125604732-125801599 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 54.70 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

7296 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918361	protein coding gene	Chr1:125604725-125804132 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016416	protein coding gene	Chr1:128774543-128986523 (+)
A/J	MGP_AJ_G0016399	protein coding gene	Chr1:124040083-124239441 (+)
AKR/J	MGP_AKRJ_G0016364	protein coding gene	Chr1:127667063-127868252 (+)
BALB/cJ	MGP_BALBcJ_G0016359	protein coding gene	Chr1:124390284-124596299 (+)
C3H/HeJ	MGP_C3HHeJ_G0016185	protein coding gene	Chr1:127865611-128072824 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016820	protein coding gene	Chr1:133645244-133858373 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014533	protein coding gene	Chr1:117438605-117641947 (+)
CAST/EiJ	MGP_CASTEiJ_G0015766	protein coding gene	Chr1:126779256-126994518 (+)
CBA/J	MGP_CBAJ_G0016158	protein coding gene	Chr1:138144969-138350411 (+)
DBA/2J	MGP_DBA2J_G0016264	protein coding gene	Chr1:123042078-123243359 (+)
FVB/NJ	MGP_FVBNJ_G0016263	protein coding gene	Chr1:121783025-121984866 (+)
LP/J	MGP_LPJ_G0016335	protein coding gene	Chr1:130117685-130329028 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016288	protein coding gene	Chr1:144094917-144314463 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016856	protein coding gene	Chr1:127438111-127644865 (+)
PWK/PhJ	MGP_PWKPhJ_G0015552	protein coding gene	Chr1:122018757-122221215 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015340	protein coding gene	Chr1:126365264-126588650 (+)
WSB/EiJ	MGP_WSBEiJ_G0015828	protein coding gene	Chr1:127387233-127597204 (+)

Human Ortholog

GPR39, G protein-coupled receptor 39

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR39, G protein-coupled receptor 39
Synonyms

ZnR
Links

HGNC:4496

NCBI Gene ID: 2863

UniProt: O43194
Chr Location

2q21.2; chr2:132416805-132646582 (+) GRCh38

MGI Vertebrate Homology

Gpr39 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR39
Gene Tree

Gpr39

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Phenotype Summary

19 phenotypes from 4 alleles in 4 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

7
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Gpr39
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display abnormal glucose homeostasis when fed a high sugar diet. Mice homozygous for a different null allele have accelerated gastric emptying, decreased fasting-induced hyperphagia, and increasedbody weight after oneyear of age.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN gpr39

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All Sequences

35
RefSeq

2
UniProt

4
CCDS

CCDS48344.1

Ensembl

ENSMUSG00000026343 (Evidence)
NCBI Gene

71111

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026343	Ensembl Gene Model \| MGI Sequence Detail	196868	C57BL/6J	± kb
transcript	ENSMUST00000027581	Ensembl \| MGI Sequence Detail	2691	Not Applicable
polypeptide	ENSMUSP00000027581	Ensembl \| MGI Sequence Detail	456	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001532 G-protein coupled receptor 39

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR052676 Zinc-sensing G-protein coupled receptor
GlyGen

Q5U431 2 sites

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All nucleic 5

cDNA 4

Primer pair 1

Microarray probesets 3

Summaries

All 56

Gene Ontology 8

Phenotypes 30
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:359119 Ramadoss S, et al., Bone-marrow macrophage-derived GPNMB protein binds to orphan receptor GPR39 and plays a critical role in cardiac repair. Nat Cardiovasc Res. 2024 Nov;3(11):1356-1373

TSS for Gpr39:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8444	Chr1:125604585-125604592 (+)	-143 bp
Tssr8445	Chr1:125604598-125604611 (+)	-127 bp
Tssr8446	Chr1:125604622-125604632 (+)	-105 bp
Tssr8447	Chr1:125604706-125604752 (+)	-3 bp
Tssr8448	Chr1:125604757-125604812 (+)	53 bp
Tssr189	Chr1:125604832-125604839 (+)	104 bp
Tssr8449	Chr1:125604850-125604859 (+)	123 bp
Tssr8450	Chr1:125604868-125604879 (+)	142 bp
Tssr8451	Chr1:125604893-125604905 (+)	167 bp
Tssr8452	Chr1:125604933-125604946 (+)	208 bp
Tssr8453	Chr1:125604955-125604970 (+)	231 bp
Tssr8454	Chr1:125605024-125605039 (+)	300 bp
Tssr8455	Chr1:125605413-125605424 (+)	687 bp
Tssr8456	Chr1:125707764-125707768 (+)	103,034 bp
Tssr8457	Chr1:125767697-125767709 (+)	162,971 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24