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Ccdc136 Gene Detail
Summary
  • Symbol
    Ccdc136
  • Name
    coiled-coil domain containing 136
  • Synonyms
    4921511K06Rik, MGC:8047
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918128
    NCBI Gene: 232664
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29396296-29426954 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    671 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918128
 protein coding gene Chr6:29396296-29426987 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030522
 protein coding gene Chr6:27188162-27218932 (+)
A/J MGP_AJ_G0030495
 protein coding gene Chr6:26036984-26067682 (+)
AKR/J MGP_AKRJ_G0030422
 protein coding gene Chr6:26898367-26929122 (+)
BALB/cJ MGP_BALBcJ_G0030505
 protein coding gene Chr6:26193182-26224356 (+)
C3H/HeJ MGP_C3HHeJ_G0030218
 protein coding gene Chr6:26896729-26927342 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030959
 protein coding gene Chr6:27974211-28005965 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028170
 protein coding gene Chr6:24244396-24274773 (+)
CAST/EiJ MGP_CASTEiJ_G0029620
 protein coding gene Chr6:26694432-26727778 (+)
CBA/J MGP_CBAJ_G0030196
 protein coding gene Chr6:29016875-29051403 (+)
DBA/2J MGP_DBA2J_G0030340
 protein coding gene Chr6:25979931-26015063 (+)
FVB/NJ MGP_FVBNJ_G0030294
 protein coding gene Chr6:25737562-25768583 (+)
LP/J MGP_LPJ_G0030427
 protein coding gene Chr6:27321482-27352147 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030330
 protein coding gene Chr6:31533205-31565270 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030989
 protein coding gene Chr6:26772780-26804219 (+)
PWK/PhJ MGP_PWKPhJ_G0029334
 protein coding gene Chr6:25516563-25547612 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029170
 protein coding gene Chr6:26490612-26523075 (+)
WSB/EiJ MGP_WSBEiJ_G0029696
 protein coding gene Chr6:26743907-26774468 (+)



Homology
more
  • Human Ortholog
    CCDC136, coiled-coil domain containing 136
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC136, coiled-coil domain containing 136
  • Synonyms
    NAG6
  • Links
    NCBI Gene ID: 64753
    neXtProt AC: NX_Q96JN2
    UniProt: Q96JN2

  • Chr Location
    7q32.1; chr7:128790757-128822132 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility, globozoospermia, asthenozoospermia, and decreased in vitro fertilization frequency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    13
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232664 NCBI Gene Model | MGI Sequence Detail 30659 C57BL/6J ±  kb
    transcript NM_001347071 RefSeq | MGI Sequence Detail 3887 C57BL/6  
    polypeptide Q3TVA9 UniProt | EBI | MGI Sequence Detail 1136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000030547 coiled-coil domain-containing protein 136
      (term hierarchy)
    • InterPro Domains
      IPR051176 Centrosomal and Immune Signaling Modulators
    • GlyGen
      Q3TVA9 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2385256
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory