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Wfdc1 Gene Detail
Summary
  • Symbol
    Wfdc1
  • Name
    WAP four-disulfide core domain 1
  • Synonyms
    2310058A03Rik, ps20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915116
    NCBI Gene: 67866
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:120393104-120414759 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 68.15 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    876 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915116
 protein coding gene Chr8:120393104-120414961 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034190
 protein coding gene Chr8:123009333-123032081 (+)
A/J MGP_AJ_G0034170
 protein coding gene Chr8:117941475-117963166 (+)
AKR/J MGP_AKRJ_G0034097
 protein coding gene Chr8:121364608-121391064 (+)
BALB/cJ MGP_BALBcJ_G0034164
 protein coding gene Chr8:118146083-118168601 (+)
C3H/HeJ MGP_C3HHeJ_G0033875
 protein coding gene Chr8:122091397-122112807 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034684
 protein coding gene Chr8:127116886-127145220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031626
 protein coding gene Chr8:110834639-110860767 (+)
CAST/EiJ MGP_CASTEiJ_G0033202
 protein coding gene Chr8:122039291-122058932 (+)
CBA/J MGP_CBAJ_G0033848
 protein coding gene Chr8:131744982-131774840 (+)
DBA/2J MGP_DBA2J_G0034004
 protein coding gene Chr8:117160606-117182799 (+)
FVB/NJ MGP_FVBNJ_G0033947
 protein coding gene Chr8:116193782-116218776 (+)
LP/J MGP_LPJ_G0034093
 protein coding gene Chr8:123145695-123172350 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033994
 protein coding gene Chr8:134183479-134222941 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034702
 protein coding gene Chr8:121516488-121539422 (+)
PWK/PhJ MGP_PWKPhJ_G0032904
 protein coding gene Chr8:116917916-116940720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032744
 protein coding gene Chr8:120216987-120238347 (+)
WSB/EiJ MGP_WSBEiJ_G0033318
 protein coding gene Chr8:122237746-122259392 (+)



Homology
more
  • Human Ortholog
    WFDC1, WAP four-disulfide core domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WFDC1, WAP four-disulfide core domain 1
  • Synonyms
    PS20
  • Links
    NCBI Gene ID: 58189
    UniProt: Q9HC57

  • Chr Location
    16q24.1; chr16:84294846-84329844 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for a null allele exhibit decreased susceptibility to influenza A virus infection and enhanced wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    16
  • cDNA Data
    21
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67866 NCBI Gene Model | MGI Sequence Detail 21656 C57BL/6J ±  kb
    transcript NM_023395 RefSeq | MGI Sequence Detail 1169 C57BL/6  
    polypeptide Q9ESH5 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:80559 Larsen M, et al., The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. Mamm Genome. 2000 Sep;11(9):767-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory