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Ctu2 Gene Detail
Summary
  • Symbol
    Ctu2
  • Name
    cytosolic thiouridylase subunit 2
  • Synonyms
    2310061F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914215
    NCBI Gene: 66965
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123202882-123209831 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    225 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914215
 protein coding gene Chr8:123202882-123210877 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034228
 protein coding gene Chr8:126015803-126026969 (+)
A/J MGP_AJ_G0034208
 protein coding gene Chr8:120801157-120808928 (+)
AKR/J MGP_AKRJ_G0034135
 protein coding gene Chr8:124319773-124327426 (+)
BALB/cJ MGP_BALBcJ_G0034202
 protein coding gene Chr8:121002240-121009917 (+)
C3H/HeJ MGP_C3HHeJ_G0033913
 protein coding gene Chr8:125017621-125025690 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034722
 protein coding gene Chr8:130218150-130227420 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031664
 protein coding gene Chr8:113636347-113644100 (+)
CAST/EiJ MGP_CASTEiJ_G0033240
 protein coding gene Chr8:125098377-125106476 (+)
CBA/J MGP_CBAJ_G0033886
 protein coding gene Chr8:135007603-135019290 (+)
DBA/2J MGP_DBA2J_G0034042
 protein coding gene Chr8:119991972-119999876 (+)
FVB/NJ MGP_FVBNJ_G0033985
 protein coding gene Chr8:119135783-119143537 (+)
LP/J MGP_LPJ_G0034131
 protein coding gene Chr8:126142420-126150686 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034032
 protein coding gene Chr8:137186883-137194786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034740
 protein coding gene Chr8:124503099-124511010 (+)
PWK/PhJ MGP_PWKPhJ_G0032942
 protein coding gene Chr8:119812661-119820896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032782
 protein coding gene Chr8:123228222-123235553 (+)
WSB/EiJ MGP_WSBEiJ_G0033356
 protein coding gene Chr8:125259758-125268420 (+)



Homology
more
  • Human Ortholog
    CTU2, cytosolic thiouridylase subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTU2, cytosolic thiouridylase subunit 2
  • Synonyms
    C16orf84, MFRG, NCS2, UPF0432
  • Links
    NCBI Gene ID: 348180
    neXtProt AC: NX_Q2VPK5
    UniProt: Q2VPK5

  • Chr Location
    16q24.3; chr16:88706483-88715396 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66965 NCBI Gene Model | MGI Sequence Detail 6950 C57BL/6J ±  kb
transcript NM_153775 RefSeq | MGI Sequence Detail 3066 C57BL/6  
polypeptide Q3U308 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006039 cytoplasmic tRNA 2-thiolation protein 2
    (term hierarchy)
  • InterPro Domains
    IPR019407 Cytoplasmic tRNA 2-thiolation protein 2
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
  • GlyGen
    Q3U308 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory