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Tmem107 Gene Detail
Summary
  • Symbol
    Tmem107
  • Name
    transmembrane protein 107
  • Synonyms
    1110004B13Rik, 2810049P21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914160
    NCBI Gene: 66910
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68961635-68964119 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.35 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914160
 protein coding gene Chr11:68961632-68964119 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018516
 protein coding gene Chr11:69476629-69479076 (+)
A/J MGP_AJ_G0018485
 protein coding gene Chr11:66861720-66864207 (+)
AKR/J MGP_AKRJ_G0018454
 protein coding gene Chr11:68860836-68863323 (+)
BALB/cJ MGP_BALBcJ_G0018456
 protein coding gene Chr11:67183774-67186261 (+)
C3H/HeJ MGP_C3HHeJ_G0018269
 protein coding gene Chr11:68881403-68883890 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018908
 protein coding gene Chr11:71586380-71588867 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016552
 protein coding gene Chr11:63800798-63803788 (+)
CAST/EiJ MGP_CASTEiJ_G0017825
 protein coding gene Chr11:69120805-69123371 (+)
CBA/J MGP_CBAJ_G0018243
 protein coding gene Chr11:74793898-74796385 (+)
DBA/2J MGP_DBA2J_G0018352
 protein coding gene Chr11:66461979-66464427 (+)
FVB/NJ MGP_FVBNJ_G0018342
 protein coding gene Chr11:66083115-66085602 (+)
LP/J MGP_LPJ_G0018423
 protein coding gene Chr11:70063340-70065826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018365
 protein coding gene Chr11:75423986-75426473 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018949
 protein coding gene Chr11:69108778-69111265 (+)
PWK/PhJ MGP_PWKPhJ_G0017600
 protein coding gene Chr11:67097922-67100369 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017388
 protein coding gene Chr11:68944794-68947267 (+)
WSB/EiJ MGP_WSBEiJ_G0017878
 protein coding gene Chr11:68751961-68754450 (+)



Homology
more
  • Human Ortholog
    TMEM107, transmembrane protein 107
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM107, transmembrane protein 107
  • Synonyms
    GRVS638, JBTS29, MKS13, PRO1268
  • Links
    NCBI Gene ID: 84314
    neXtProt AC: NX_Q6UX40
    UniProt: Q6UX40

  • Chr Location
    17p13.1; chr17:8172457-8176399 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TMEM107 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice homozygous for an ENU induced allele exhibit preaxial polydactyly, exencephaly, microphthalmia, cleft palate, craniofacial defects, short sternum, split sternum and absent floor plate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    12
  • cDNA Data
    26
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66910 NCBI Gene Model | MGI Sequence Detail 2485 C57BL/6J ±  kb
    transcript NM_028336 RefSeq | MGI Sequence Detail 1271 C57BL/6  
    polypeptide Q9CPV0 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919975
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:342023 Dubaic M, et al., Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Life Sci Alliance. 2023 Dec;6(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory