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Slc27a1 Gene Detail
Summary
  • Symbol
    Slc27a1
  • Name
    solute carrier family 27 (fatty acid transporter), member 1
  • Synonyms
    Fatp, FATP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347098
    NCBI Gene: 26457
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72021526-72039946 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM, cytoband B3.3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    412 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347098
 protein coding gene Chr8:72021372-72039951 (+)
129S1/SvImJ ENSMUSG00200031188
 protein coding gene Chr8:66618973-66636724 (+)
A/J ENSMUSG00195015593
 protein coding gene Chr8:67066823-67084641 (+)
AKR/J ENSMUSG00220021546
 protein coding gene Chr8:67104104-67121830 (+)
BALB/cJ ENSMUSG00180026436
 protein coding gene Chr8:66801981-66819730 (+)
C3H/HeJ ENSMUSG00175019166
 protein coding gene Chr8:67004221-67021973 (+)
C57BL/6NJ ENSMUSG00215021649
 protein coding gene Chr8:66579141-66596970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031194
 protein coding gene Chr8:63679097-63701190 (+)
CAST/EiJ ENSTCUG00005038068
 protein coding gene Chr8:66607967-66626271 (+)
CBA/J ENSMUSG00210034312
 protein coding gene Chr8:66847814-66865564 (+)
DBA/2J ENSMUSG00185011922
 protein coding gene Chr8:73007452-73025203 (+)
FVB/NJ ENSMUSG00205024386
 protein coding gene Chr8:66099787-66117536 (+)
JF1/MsJ ENSUMUG00000014283
 protein coding gene Chr8:75275187-75292943 (+)
LP/J ENSMUSG00230033002
 protein coding gene Chr8:76619115-76636866 (+)
NOD/ShiLtJ ENSMUSG00190027399
 protein coding gene Chr8:66762309-66780123 (+)
NZO/HlLtJ ENSMUSG00225046477
 protein coding gene Chr8:80019055-80036803 (+)
PWK/PhJ ENSLUMG00010029190
 protein coding gene Chr8:66741321-66759115 (+)
SPRET/EiJ ENSMSPG00010039956
 protein coding gene Chr8:68424755-68442551 (+)
WSB/EiJ ENSIUOG00005021076
 protein coding gene Chr8:67615098-67632813 (+)



Homology
more
  • Human Ortholog
    SLC27A1, solute carrier family 27 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC27A1, solute carrier family 27 member 1
  • Synonyms
    ACSVL5, FATP, FATP-1, FATP1
  • Links
    NCBI Gene ID: 376497
    UniProt: Q6PCB7

  • Chr Location
    19p13.11; chr19:17467666-17506190 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are protected from fat-induced insulin resistance and intramuscular accumulation of fatty acid metabolites without alterations in whole body adiposity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1117
  • Tissues
    161
  • cDNA Data
    62
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031808 Ensembl Gene Model | MGI Sequence Detail 18421 C57BL/6J ±  kb
    transcript ENSMUST00000034267 Ensembl | MGI Sequence Detail 2795 Not Applicable  
    polypeptide ENSMUSP00000034267 Ensembl | MGI Sequence Detail 646 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 3
      cDNA 62
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19704, MGI:102796
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 17
      Gene Ontology 30
      Phenotypes 17
    • Earliest
      J:21397 Schaffer JE, et al., Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein [see comments]. Cell. 1994 Nov 4;79(3):427-36
    • Latest
      J:353478 Farley A, et al., Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. Cells. 2024 Aug 13;13(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory